Mesothelioma Information, Treatment And ClinicMesothelioma Information, Treatment And ClinicThis blog contains comprehensive information about mesothelioma, includes treatment options, prevention, it's risk, fact and symptoms, article, news, doctor, hospital and clinic that have speciality in mesothelioma, statistics and step-by-step for he Articles
Mesothelioma by ONCONASE
2008-02-25 01:51:00 mesothelioma clinicAlfacell Corporation (Nasdaq: ACEL) announced that in vitro and in vivo data presented at the 5th Cancer Drug Research & Development conference show the genes affected and biological pathways impacted by ONCONASE stimulated intracellular events as revealed by expression profiling of human malignant mesothelioma cell lines. Data presented also show that ONCONASE conjugates effectively kill human cancer cells in cell culture and murine models of cancer.The data demonstrated that 181 genes were consistently up- and down-regulated by ONCONASE and that the genes involved in triggering apoptosis (programmed cell death) and the intracellular MAPK signaling pathway were impacted by ONCONASE in vitro. Additionally, pre-clinical data in mice demonstrated the relative potency of chemical conjugates of ONCONASE. These findings further support the research of next generation targeted ONCONASE fusion proteins in an effort to develop compounds with improved mesothelioma tumo... More About: Mesothelioma
Mesothelioma Gathering
2008-02-19 22:43:00 mesothelioma clinicVictims of asbestos-related cancer and their families will gather for a tree planting ceremony to raise awareness of the disease 'time bomb' in Plymouth. To be held in the grounds of Saltram House, Plympton, on February 27 which is national Action Mesothelioma Day (AMD), organised by Jackie Lowe ( launched the Roger Lowe Asbestos Mesothelioma Campaign in memory of her dockyard worker father. Mr Lowe died of the cancer aged 68 in December 2005.)Why at Plymouth ?, because Plymouth has been identified as the UK's fourth largest 'hotspot' for the disease, with 320 people dying from mesothelioma caused by asbestos between 1985 and 2004. Cases are expected to peak between 2011 and 2015, as the condition takes between 30 to 40 years to emerge.Jackie, want to raise awareness of all asbestos-related conditions. The day is also about tying in Plymouth with the rest of the country. Despite our unfortunate links with asbestos-related conditions, it has taken a long time... More About: Gathering
Treatment for unresectable malignant mesothelioma (UMM)
2008-01-19 11:46:00 mesothelioma clinicAlfacell corporation announced that it participated in an acquisition and in a supplying agreement with scientific protein laboratory LLC (SPL) for the commercial production of ONCONASE(R) (ranpirnase). ONCONASE, the drug candidate line of the company, is evaluated at present as treatment for unresectable malicious Mesothelioma (UMM) in confirming phase IIIb a clinical attempt."SPL was referred into production of ONCONASE of the all first rows,", said Kuslima Shogen, general manager von Alfacell. "we are with the great achievement that extremely wohlen qualified crew at the SPL for many years fallen and are convinced that the commercial production of ONCONASE in the right hands is. This agreement is another step, which is for Alfacell forward, there we plans for the commercialization of ONCONASE." "we are over the Alfacell project of very much begin," very enthusiastisch been, said David Strunce, president and general manager of SPL. "we are by the way impressed, ... More About: Treatment , Elio
Saying the final farewell to loved ones. The last 48 hours
2008-01-15 09:37:00 mesothelioma clinic HE has battled for two long years. Unfortunately the patient’s lung cancer progressed despite three lines of chemotherapy. He drifts in and out of consciousness. Intravenous morphine takes the edge off his pain and suffering. Death is imminent. It will come in 24 to 72 hours. Cancer testing and cancer treatment – stop. Care continues. Clinical findings – rather than repeated blood tests and x-rays – determine symptomatic and supportive treatment. The relatives and friends understand. There is a hush in the room. The wife silently hugs her three children. Two siblings and three close friends are in quiet meditation. She recalls their times together and knows that most everything will be changed soon. The others are there for her. Bach’s Air on the G string (his favourite baroque piece) is being played. They all reflect on their own lives and how the patient has enriched theirs. It is a time of contemplation and soul searching about the meaning o... More About: Final , Farewell , Hours
Wrexham cancer sufferer sues for £200,000
2008-01-05 00:45:00 mesothelioma clinicA PENSIONER who claims his job caused a devastating cancer is suing a North Wales council for up to £200,000 in damages.Raymond Jones, 74, from Wrexham, has filed a writ in the High Court, claiming damages of between £150,000 and £200,000 against Wrexham Council.He claims that he contracted the industrial lung disease mesothelioma after prolongued exposure to asbestos and asbestos dust in the 30 years he worked on housing repairs and building inspections.Mr Jones, of Bieston Close, off Barkers Lane, says the councils failed to provide him with respiratory protection.Between 1961 and 1991 Mr Jones was employed by Wrexham Rural District Council and Wrexham Metropolitan District Council on housing repairs and then inspections – which are covered by construction and asbestos legislation.“He worked in buildings under demolition, alteration and construction and on many occasions worked in close proximity to asbestos based lagging being stripped, mixed and applied... More About: Cancer
Mesothelioma Clinic Issues
2007-12-23 12:21:00 mesothelioma clinicA SOUTH Tyneside widow today blasted a £1,800 increase in asbestos bereavement compensation as "a slap in the face".Anne Craig, from St Joseph's Court, Hebburn, received £10,000 in compensation after her husband David died from mesothelioma in February 2002.But she says she finds it "shocking" that people in Scotland receive tens of thousands of pounds more in compensation.Her comments follow the Government's decision to increase bereavement compensation by £1,800 in England and Wales, to £11,800.But Scottish widows and widowers of mesothelioma victims receive up to £30,000 compensation for bereavement.Mrs Craig has backed a campaign by Newcastle-based Thompsons Solicitors to bridge the compensation gap between England, Wales and Scotland.She said: "This announcement is like a slap in the face for the families of people who have died from asbestos diseases." Mrs Craig added: "No amount of money can bring David back, but the level of compensation paid for be... More About: Issues , Mesothelioma , Issue , Elio
Widow's anger at asbestos payout
2007-12-23 12:21:00 mesothelioma clinicA SOUTH Tyneside widow today blasted a £1,800 increase in asbestos bereavement compensation as "a slap in the face".Anne Craig, from St Joseph's Court, Hebburn, received £10,000 in compensation after her husband David died from mesothelioma in February 2002.But she says she finds it "shocking" that people in Scotland receive tens of thousands of pounds more in compensation.Her comments follow the Government's decision to increase bereavement compensation by £1,800 in England and Wales, to £11,800.But Scottish widows and widowers of mesothelioma victims receive up to £30,000 compensation for bereavement.Mrs Craig has backed a campaign by Newcastle-based Thompsons Solicitors to bridge the compensation gap between England, Wales and Scotland.She said: "This announcement is like a slap in the face for the families of people who have died from asbestos diseases." Mrs Craig added: "No amount of money can bring David back, but the level of compensation paid for be... More About: Anger
Man suffering from lung disease crusades against asbestos
2007-12-11 00:02:00 mesothelioma clinicSarah, Phil and young Sarah Lake have made decisions about his healthcare as a family. Phil, a former millright, has lived with a rare cancer called mesothelioma for eight years. They say every day is blessed, despite his illness. .. SCOTT DEPOT — Phil Lake greets each new day with both the best and worst news. He awakens to know he has survived a terrible disease another day. Yet he knows he cannot forever survive the disease, a rare cancer called mesothelioma that has attacked the tissue that covers his lungs. He has had one lung and part of the other removed. A Gortex patch has replaced his diaphragm. He has undergone numerous rounds of chemotherapy and radiation. But here's the thing: Phil Lake, 47, husband of Sarah, father of a girl by the same name, looks good. He's trim but certainly not gaunt. His cheeks are ruddy, not pale. He has a firm hand... More About: Crusades , Disease , Suffering , Erin
Mesothelioma Treatment
2007-12-06 18:38:00 mesothelioma clinicTreatment of mesothelioma using conventional therapies has not proved successful and patients have a mediam survival time of 6 - 12 months after presentation. The clinical behaviour of the malignancy is affected by several factors including the continuous mesothelial surface of the pleural cavity which favours local metastasis via exfoliated cells, invasion to underlying tissue and other organs within the pleural cavity, and the extremely long latency period between asbestos exposure and development of the disease.Surgery, either by itself or used in combination with pre- and post-operative adjuvant therapies has proved disappointing with a 5 year survival rate of less than 10%. A pleurectomy/decortication is the most common surgery, in which the lining of the chest is removed. Less common is an extrapleural pneumonectomy (EPP), in which the lung, lining of the inside of the chest, the hemi-diaphragm and the pericardium are removed.Although the tumor is highly res... More About: Mesothelioma , Elio
How is mesothelioma diagnosed?
2007-09-19 19:33:00 mesothelioma clinicDiagnosing mesothelioma is often difficult, because the symptoms are similar to those of a number of other conditions. Diagnosis begins with a review of the patient’s medical history, including any history of asbestos exposure. A complete physical examination may be performed, including x-rays of the chest or abdomen and lung function tests. A CT (or CAT) scan or an MRI may also be useful. A CT scan is a series of detailed pictures of areas inside the body created by a computer linked to an x-ray machine. In an MRI, a powerful magnet linked to a computer is used to make detailed pictures of areas inside the body. These pictures are viewed on a monitor and can also be printed.A biopsy is needed to confirm a diagnosis of mesothelioma. In a biopsy, a surgeon or a medical oncologist (a doctor who specializes in diagnosing and treating cancer) removes a sample of tissue for examination under a microscope by a pathologist. A biopsy may be done in different ways, depen... More About: Mesothelioma , Elio
Mesothelioma Staging Systems
2007-09-06 13:29:00 mesothelioma clinicStaging is the process of finding out how far the cancer has spread. Staging of mesothelioma is based on imaging studies such as x-rays, CT scans, and MRI scans.Butchart Staging System: Stage I: Mesothelioma is present within the right or left pleura, and may also involve the lung, pericardium, or diaphragm (the muscle separating the chest from the abdomen) on the same side. Stage II: Mesothelioma invades the chest wall or involves the esophagus (food passage connecting the throat to the stomach), heart, or pleura on both sides. The lymph nodes in the chest may also be involved. Stage III: Mesothelioma has penetrated through the diaphragm into the peritoneum (lining of the abdominal cavity). Lymph nodes beyond those in the chest may also be involved. Stage IV: There is evidence of distant metastases (spread through the bloodstream to other organs). Once the diagnosis is confirmed... More About: Systems , Elio
Symptoms of mesothelioma
2007-08-17 06:22:00 mesothelioma clinicSymptoms of mesothelioma may not appear until 20 to 50 years after exposure to asbestos. Shortness of breath, cough, and pain in the chest due to an accumulation of fluid in the pleural space are often symptoms of pleural mesothelioma.Symptoms of peritoneal mesothelioma include weight loss, abdominal swelling and pain due to ascites (a buildup of fluid in the abdominal cavity). Other symptoms of peritoneal mesothelioma may include bowel obstruction, blood clotting abnormalities, anemia and fever. If the cancer has spread beyond the mesothelium to other parts of the body, symptoms may include pain, trouble swallowing, or swelling of the neck or face.These symptoms may be caused by mesothelioma or by other, less serious conditions. Mesothelioma that affects the pleura can cause these signs and symptoms: chest wall pain pleural effusion, or fluid surrounding the lung shortness of breath wheezing, hoarseness, or coughIn severe cases, the person may have ma... More About: Elio
Types of Mesothelioma
2007-08-08 12:55:00 mesothelioma clinicThere are two common types of mesothelioma:Pleural Mesothelioma - is cancer of the Pleura, a sac that lines the lungs. Is much more common than mesothelioma in the peritoneum. For every person with peritoneal mesothelioma there will be about 12 people who have pleural mesothelioma. and causes thickening of the membranes surrounding the abdominal organs and a collection of fluid in the abdomen. The collection of fluid is called ascites and causes swelling of the abdomen.Peritoneal Mesothelioma- Cancer in the abdomen caused by asbestos is known as Peritoneal Mesothelioma. The peritoneal is a sac that lines the abdomen much in the same way the pleura lines the lungs. It is believed that asbestos fibers reach the peritoneal membrane either by being swallowed or migrating from the pleura. The lining of the abdomen is known as the peritoneum. It also has two layers: the inner (visceral) layer, which is next to the abdominal organs; and t... More About: Types , Elio
Who is at increased risk for developing mesothelioma?
2007-08-08 09:50:00 mesothelioma clinicAsbestos has been mined and used commercially since the late 1800s. Its use greatly increased during World War II. Since the early 1940s, millions of American workers have been exposed to asbestos dust. Initially, the risks associated with asbestos exposure were not known. However, an increased risk of developing mesothelioma was later found among shipyard workers, people who work in asbestos mines and mills, producers of asbestos products, workers in the heating and construction industries, and other tradespeople. Today, the U.S. Occupational Safety and Health Administration (OSHA) sets limits for acceptable levels of asbestos exposure in the workplace. People who work with asbestos wear personal protective equipment to lower their risk of exposure.The risk of asbestos-related disease increases with heavier exposure to asbestos and longer exposure time. However, some individuals with only brief exposures have developed mesothelioma. On the other hand, not all wor... More About: Risk , Mesothelioma , Elio
What are the risk factors for mesothelioma?
2007-08-07 21:49:00 mesothelioma clinicWorking with asbestos is the major risk factor for mesothelioma. A history of asbestos exposure at work is reported in about 70 percent to 80 percent of all cases. However, mesothelioma has been reported in some individuals without any known exposure to asbestos.Asbestos is the name of a group of minerals that occur naturally as masses of strong, flexible fibers that can be separated into thin threads and woven. Asbestos has been widely used in many industrial products, including cement, brake linings, roof shingles, flooring products, textiles, and insulation. If tiny asbestos particles float in the air, especially during the manufacturing process, they may be inhaled or swallowed, and can cause serious health problems. In addition to mesothelioma, exposure to asbestos increases the risk of lung cancer, asbestosis (a noncancerous, chronic lung ailment), and other cancers, such as those of the larynx and kidney.Smoking does not appear to increase the risk of mesot... More About: Risk , Mesothelioma , Elio
What is the mesothelium?
2007-08-06 12:14:00 mesothelioma clinicThe mesothelium is a membrane that covers and protects most of the internal organs of the body. It is composed of two layers of cells: One layer immediately surrounds the organ; the other forms a sac around it. The mesothelium produces a lubricating fluid that is released between these layers, allowing moving organs (such as the beating heart and the expanding and contracting lungs) to glide easily against adjacent structures.The mesothelium has different names, depending on its location in the body. The peritoneum is the mesothelial tissue that covers most of the organs in the abdominal cavity. The pleura is the membrane that surrounds the lungs and lines the wall of the chest cavity. The pericardium covers and protects the heart. The mesothelial tissue surrounding the male internal reproductive organs is called the tunica vaginalis testis. The tunica serosa uteri covers the internal reproductive organs in women.
Mesothelioma History
2007-08-05 17:16:00 mesothelioma clinicIt was not until 1960 that an article published by Wagner et al first officially established mesothelioma as a disease arising from exposure to crocidolite asbestos. The article referred to over 30 case studies of people who had suffered from mesothelioma in South Africa. Some exposures were transient and some were mine workers. In 1962 McNulty reported the first diagnosed case of malignant mesothelioma in an Australian asbestos worker. The worker had worked in the mill at the asbestos mine in Wittenoom from 1948 to 1950.In the town of Wittenoom, asbestos-containing mine waste was used to cover schoolyards and playgrounds. In 1965 an article in the British Journal of Industrial Medicine established that people who lived in the neighbourhoods of asbestos factories and mines, but did not work in them, had contracted mesothelioma.Despite proof that the dust associated with asbestos mining and milling causes asbestos related disease, mining began at Wittenoom in 1943... More About: History , Mesothelioma , Elio
Mesothelioma Legal Issues
2007-08-05 14:36:00 mesothelioma clinicAsbestos and the lawThe first lawsuits against asbestos manufacturers were in 1929. Since then, many lawsuits have been filed against asbestos manufacturers and employers, for neglecting to implement safety measures after the links between asbestos, asbestosis, and mesothelioma became known (some reports seem to place this as early as 1898). The liability resulting from the sheer number of lawsuits and people affected has reached billions of dollars.[citation needed] The amounts and method of allocating compensation have been the source of many court cases, and government attempts at resolution of existing and future cases. More About: Issues , Legal , Mesothelioma , Issue , Elio
Mesothelioma drug to be distributed in Eastern Europe
2007-08-02 23:12:00 The maker of the drug ONCONASE, which is currently being evaluated in a Phase IIIb clinical trial for the treatment of inoperable mesothelioma–a cancer caused by asbestos–has entered into an agreement to distribute the drug in Eastern Europe . Under the agreement, ONCONASE maker Alfacell gives US Pharma exclusive rights to market, sell and distribute ONCONASE in Poland, Belarus, Ukraine, Latvia and Lithuania. Alfacell will be responsible for regulatory filings and marketing approval from the European Medicines Agency as well as the manufacture and supply of the drug.For the full story, go to http://money.cnn.com/news/. More About: Drug , Mesothelioma , Tribute
What is Mesothelioma
2007-08-02 17:06:00 Mesothelioma is a cancer that is deadly, found in people that have had exposure to asbestos. Asbestos finds its victims as it floats through the air. These airborne particles are taken into the body by unsuspecting people by simply breathing. They then get trapped within the thin lining that is inside the lungs. There is an estimated minimum of 2,500 individuals per year that are diagnosed with this deadly cancer.Although asbestos has been banned in the 1970s, there is still a severe risk today for ingesting these tiny particles. Mesothelioma has a long term inactive time. In some cases, it can be stagnant for up to 50 years before the effects are acknowledged. A vast majority of the sufferers of mesothelioma were exposed to the asbestos while working in construction jobs, doing brake work to elevators, and even in power plants and shipyards. The main timeframe for ingesting the asbestos has been narrowed down to the 1950's through the 1970's.Asbestos continues to be a serious iss... More About: Mesothelioma , Elio |
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