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Viagra's Mechanism of Action, Contraindications, and Side effects.
2008-02-11 10:09:00 Mechanism of Action Part of the physiological process of erection involves the parasympathetic nervous system causing the release of nitric oxide (NO) in the corpus cavernosum of the penis. NO binds to the receptors of the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation (vasodilation) of the intimal cushions of the helicine arteries, resulting in increased inflow of blood and an erection.Sildenafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. The molecular structure of sildenafil is similar to that of cGMP and acts as a competitive binding agent of PDE5 in the corpus cavernosum, resulting in more cGMP and better erections. Without sexual stimulation, and therefore lack of activation of the NO/cGMP system, sildenafil should not cause an erection. Other drugs that operate by the same mecha... More About: Side , Side Effects , Effects , Mechanism
Viagra
2008-02-11 09:53:00 Sildenafil citrate, sold under the names Viagra , Revatio and under various other names, is a drug used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH), developed by the pharmaceutical company Pfizer. Its primary competitors on the market are tadalafil (Cialis), and vardenafil (Levitra).Systematic (IUPAC) name 1-[4-ethoxy-3-(6,7-dihydro-1-methyl-7-oxo -3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-y l)phenylsulfonyl]-4-methylpiperazine citrate Identifiers:CAS number : 139755-83-2 ATC code : G04BE03 PubChem : 5281023 DrugBank : APRD00556 Chemical data Formula : C22H30N6O4S Mol. mass : base: 474.6 g/mol SMILES : eMolecules & PubChem Pharmacokinetic data Bioavailability :40% Metabolism Hepatic Half... |
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