Autism PreventionAutism PreventionAutism Prevention is possible because a good part of what is today called autism is caused by spontaneous mutations that accumulate in the sperm making cells, called spermatagonia, as men age. Fathering babies earlier in life and cryopreserving seme 
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"For example, epigenetics could explain why older men have a higher risk of
2008-03-19 01:54:00 More important posts from the Simons Foundation blogposted by ApoorvaMandavilliKeeping sperm swimmingly healthy20 February 2008 16:53:00 EST Earlier this week, I blogged about the risk of autism during pregnancy. But before anyone starts to blame mothers again, let me clarify that autism risk can also be affected by the father’s health.Men who smoke and drink are essentially exposing themselves to environmental toxins that could damage their sperm, that much is already known. But according to research presented earlier this week at the American Association for the Advancement of Science (AAAS) meeting in Boston, those defects can be passed down to children and persist even four generations on.What is interesting here is that these changes are epigenetic – chemical modifications that can switch a gene on or off, without altering the actual genetic sequence.There’s been some debate about whether epigenetic changes can be passed on to children but in recent years, scientists hav... More About: Risk , Higher
Gerald Fishbach is Probably Right! Read On to understand the connection.
2008-03-18 03:22:00 "It may be a quantitative issue - more or less gene expression rather than a yes or no matter. Deletions in autism and duplications in schizophrenia of the same piece of DNA is an astounding finding!"One gene, many diseases28 February 2008 16:34:00 EST Could the same genetic factors that cause autism also be responsible for bipolar disease, schizophrenia and other mental illnesses?I was at an autism conference in Santa Fe this week and among the many fascinating things I learned, this was one that really piqued my interest.In the last year, the idea that copy number variations (CNVs) are associated with autism has really taken hold among researchers. These CNVs are deletions or duplications of a chunk of DNA, and they may cause diseases by affecting the dosage — too much or too little — of a particular gene product.Jonathan Sebat, who last year published one of the first CNV/autism papers, says the rate at which CNVs appear is about 100-fold higher than for single nucleotide po... More About: Connection , Read , Understand
Christopher Stevens Tells of His Son's Autism, Paternal Age Probably Is Re
2008-03-16 03:28:00 From the Guardian http://www.guardian.co.uk/society/2008/ma r/16/mentalhealthHow our son taught us the secret songs of autism.David is 11 and profoundly autistic, one of half a million Britons with a condition for which there is no cure. Christopher Stevens tells of his family's struggle to understand their son's inner worldChristopher Stevens The Observer, Sunday March 16 2008 Article historyAbout this articleClose This article appeared in the Observer on Sunday March 16 2008 on p34 We couldn't see David but we could hear him. He was singing. And the frightening thing was that we hadn't heard the tune before.Our son is profoundly autistic. He can't communicate with words. His life has a language of its own, though, a musical soundtrack which he supplies. All his moods and activities are linked to songs - the snatches of melody which mean he's anxious, or blissfully content, or embarking on mischief.This song, though, was a new one. David had darted upstairs and my wife Nic... More About: Autism , Tells
What Happens to Some Babies After Vaccinations
2008-03-15 16:02:00 Scientific Misconduct Blog: The Osler Corner - On polypharmacy Do we know how all the vaccines given on the same day interact? More About: Babies
Link To Ginger's piece on whether it is safe to get flu shots during pregna
2008-03-14 23:42:00 Adventures in Autism: Can I Get The Flu Shot While Pregnant? More About: Link , Shots , Safe , Piece
News About Those Who Experienced Vaccine Related Autism
2008-03-13 23:00:00 Adventures in Autism : The Beginning of the End of Vaccine /Autism Secrecy More About: News , Related , Experienced
Public Health Warnings Are Needed To Encourage Fathering Babies in Ones 20s
2008-03-11 16:20:00 Below are the faces of some of the researchers, living and dead who warn or research about the role of paternal age. Leslie B. Raschka, MD, psychiatrist tried to warn and he could not get published in the major journals. See end of this post for the paper from the Chinese Medical Journal 2000.Michael Craig Miller, MD psychiatrist Harry Fisch,MD Male Fertility Finn Rasmussen Epidemiologist Avi Abraham Reichenberg, MD Psychiatrist Dolores Malaspina, MD psychiatrist James F. Crow geneticist J.B.S. Haldane geneticist Lionel Penrose Geneticist Wilhelm Weinberg Obstetrician, researcherIt was Wilhelm Weinberg in 1912 who noted that paternal age not maternal age was connected with abnormalities in offspring. THE AGE OF THE FATHER AND THEHEALTH OF FUTURE GENERATIONSWord Count: 903 Leslie B. Raschka M.D., Associate Professor (retired),Department of Psychiatry, University of TorontoAddress: 27 Edgecombe ave, Toronto, Ontario, CanadaM5N 2Xl, Tel. (416) 783-69382AbstractPurpose: To assess the ... More About: Health , Babies , Public , Public Health , Warnings
Imagine by David Archuleta
2008-03-11 05:36:00 David Archuleta More About: David , Imagine , David Archuleta
The age of parenting has been increasing in the Western world in the past t
2008-03-10 02:04:00 ExplainsResearch project up for THES award28 September 2007, PR 145/07Dr Avi Reichenberg, Institute of Psychiatry, has been shortlisted for the Research Project of the Year Award in the prestigious Times Higher Awards for his work on paternal age and autism. His was the first project to examine the relationship between older father's age and risk of autism in children.‘I am delighted to be shortlisted for a Times Higher Award. It acknowledges the importance of my research in helping us to better understand the origins of autism and related disorders,' comments Dr Reichenberg. He also recently received the College's inaugural King's Award for Research Project of the Year 2007.From 1999 to 2004, the number of new fathers aged 40 or over rose by a third, which led the Times Higher to note ‘This is why research on autism by a team led by Abraham Reichenberg has important benefits in public health as well as scientific advancement.'Autism is a severe disorder of social and langu... More About: Parenting , World , Past , Western
Are older fathers more likely to have children with autism?
2008-03-09 21:33:00 Father's advanced age feeds autism riskHelen Pearson 25 February 2008 09:00:00 ESTChildren of fathers aged 40 or older are nearly six times morelikely to have autism.Are older fathers more likely to have children with autism? A series of epidemiological studies is giving credence to the idea, suggesting that, with age, sperm may accumulate damage that increases risk in the next generation.Advancing age of the father is known to be a significant risk factor for schizophrenia1. These studies — along with anecdotal suggestions that fathers of autistic children tend to be older than average — prompted Avi Reichenberg of Mount Sinai School of Medicine, New York, to launch one of the first thorough epidemiological investigations into a link between the two.Reichenberg and his colleagues had access to a vast database of health information collected from more than 132,000 Israeli adolescents who underwent draft board assessment, including psychiatric screening, before entering the army... More About: Autism , Fathers
Imprinted Genes Epigenetics
2008-03-08 18:10:00 Excerpts- from a page on ImprintingImprinted genes are genes whose expression is determined by the parent that contributed them. Imprinted genes violate the usual rule of inheritance that both alleles in a heterozygote are equally expressed. Does advancing paternal age cause autism and schizophrenia, Alzheimer's and cancer because errors in imprinting result from age?Is imprinting important?Yes. Deliberate (in mice) or accidental (in humans) inheritance of two copies of a particular chromosome from one parent and none from the other parent is usually fatal (even though a complete genome is present). Inheritance of two copies of one of mother's genes and no copy of the father's (or vice versa) can produce serious developmental defects. Failure to inherit several nonimprinted genes on the father's chromosome #15 causes a human congenital disorder called Prader-Willi syndrome. Failure to inherit one nonimprinted gene (UBE3A) on the mother's chromosome #15 causes Angelman syndrome.... More About: Genes
Brooke White You're So Vain
2008-03-08 05:05:00 Long and Winding Road More About: White , Brooke , Vain
Vaccine Did Cause Hannah's Autism
2008-03-07 17:28:00 Debate Rages Anew on Vaccine -Autism LinkVaccine Experts Say Government Concession Does Not Amount to Clear ConnectionHannah Poling, left, stands with her parents Terry and Jon Poling, right, at a news conference in Atlanta, Thursday, March 6, 2008. Government health officials have conceded that childhood vaccines worsened a rare, underlying disorder that ultimately led to autism-like symptoms in Hannah, and that she should be paid from a federal vaccine-injury fund. (W.A.Harewood/AP Photo)By DAN CHILDSABC News Medical UnitMarch 7, 2008Top federal health authorities Thursday reiterated that vaccines do not cause autism after government health officials acknowledged that a vaccine, by worsening an underlying genetic condition, may have triggered autismlike symptoms in one girl.VideoVaccine-Autism DebateThe case is viewed as an important milestone by autism groups that maintain that vaccinations are connected to autism.But Dr. Julie Gerberding, director of the U.S. Centers for Disease ...
Very Good Article On Various Research on Paternal Age and Autism from the S
2008-03-07 01:46:00 I thank Jim Simons, Apoorva Mandavilli, Helen Pearson and the Simons Foundation for This Vital Article ! I have been harping on the topic for a year and a half.The public needs to know what is going on genetically in later fatherhood. Autism , schizophrenia, Alzheimer's, cancers, autoimmune disorders, etc. all increase in offspring.The epigenetic effects of older paternal age for instance in imprinting are probably important to look into.Father's advanced age feeds autism riskHelen Pearson25 February 2008 09:00:00 ESTChildren of fathers aged 40 or older are nearly six times morelikely to have autism.Are older fathers more likely to have children with autism? A series of epidemiological studies is giving credence to the idea, suggesting that, with age, sperm may accumulate damage that increases risk in the next generation.Advancing age of the father is known to be a significant risk factor for schizophrenia1. These studies — along with anecdotal suggestions that fathers of autistic... More About: Research , Good
Male Chimps Prefer and Compete for an Older Experienced Female to Mate With
2008-03-05 23:44:00 There is no doubting that having a baby later does present risks for both mother and baby.Miscarriage and birth defects are more common in older mothers.Recent research also links low birth weight babies and even, in those women who go on to have girls, future fertility problems for them, too.And yet, while older mothers are constantly bashed with facts and figures telling them the error of their ways, what is less well-publicised is the impact of older fathers.Research has linked fathers over 50 with high incidences of miscarriage, premature birth, autism and even schizophrenia. Yet, when Radio 4 presenter John Humphrys became a dad at 56, no one gave him a lecture about the folly of waiting so late.The career bitch who wakes up on her 40th birthday and suddenly decides she's got enough Jimmy Choo shoes and would now like to have a baby is a myth.It is much more likely that she simply didn't meet the right man at the right time.Instead of criticising women in their mid-30s for le... More About: Female , Mate , Male , Compete , Experienced
In addition to "mutational errors involved in spermatogenisis that occur wi
2008-03-05 01:48:00 on autosomal and X chromosomes are probably involved in the increase in rates of schizophrenia and autism found in the offspring of older men. The older the age of the father, the more neurodevelopmental disorders in offspring at a population level.Aberrant Epigenetic Regulation Could Explain the Relationship of Paternal Age to SchizophreniaMary C. Perrin2, Alan S. Brown3,4 and Dolores Malaspina1,2 2 Department of Psychiatry, School of Medicine, New York University, New York, NY3 New York State Psychiatric Institute, New York, NY4 Department of Psychiatry, Columbia University, New York, NY1 To whom correspondence should be addressed; tel: 212-263-6214, fax: 212-263-5717, e-mail: Dolores.Malaspina@NYUMC.ORG'//-->."Imprin ting errors could increase the risk of schizophrenia through multiple pathways including direct effects on the expression of genes involved in neuropsychiatric pathology or indirectly through imprinting errors in genes related to the normal functioning of the placen... More About: Errors
Hooray for Senator John McCain Acknowledging the Rise in Autism!
2008-03-04 05:17:00 Check PointMcCain Steps Into Debate Over Cause of Autism http://www.nytimes.com/2008/03/03/us/poli tics/03cnd-autism.html?_r=1&adxnnl=1&oref =slogin&adxnnlx=1204604160-9d/f1lzkRe1PHu 6kwWISyQ By BENEDICT CAREYPublished: March 3, 2008“It’s indisputable that autism is on the rise among children,” Senator John McCain said while campaigning recently in Texas. “The question is what’s causing it. And we go back and forth and there’s strong evidence that indicates that it’s got to do with a preservative in vaccines.”With that comment, Mr. McCain marked his entry into one of the most politicized scientific issues in a generation.Mr. McCain is correct that autism diagnoses have increased in recent decades; indeed, no one disputes that. He is on much shakier ground when talking about the preservative as a cause.While some parents’ groups and lawmakers assert that the preservative, called thimerosal, has caused an epidemic of new autism cases, most mainstream researchers strongl... More About: Rise , John McCain
If You Want to Share The Blog Press the Stumble Upon Button at the Bottom o
2008-03-04 00:24:00 &title="> Stumble It! More About: Press , Blog , Share , Button
An Important Paper From Ten Years Ago
2008-03-04 00:10:00 ----------------------------------------- --------------------------------------- Human Reproduction, Vol 13, 2371-2376, Copyright © 1998 by Oxford University Press ----------------------------------------- --------------------------------------- REVIEWS http://humrep.oxfordjournals.org/cgi/cont ent/abstract/13/9/2371Long-term effects of delayed parenthoodJJ Tarin, J Brines and A Cano Department of Paediatrics, Obstetrics and Gynaecology, Faculty of Medicine, University of Valencia, Spain. The present study aims to define, characterize and compare the long- term effects on offspring of delayed parenthood. Data published so far on this topic show that maternal and paternal ageing may affect offspring by different mechanisms. Delayed motherhood is characterized by increased probability of obstetric complications and/or fetal and perinatal problems which, in turn, may increase the risks of mortality and morbidity in newborns and later life. Furthermore, maternal ageing is distinguished ... More About: Paper , Years
Is Cell Phone Radiation Dangerous?
2008-03-03 23:51:00 http://www.dailymail.co.uk/pages/live/art icles/health/healthmain.html?in_article_i d=525268&in_page_id=1774We love our mobiles... but are we being told all the facts about how safe they are?By JEROME BURNE - More by this author » Last updated at 22:07pm on 3rd March 2008 We love our mobile phones - all 70 million of them. They are both fashion accessories and an essential part of our lives. Yet since they first became widely available in the 1990s, there have been nagging doubts about just how safe they are. Could they cause cancers in the brain? Does living near a mobile phone mast raise your risk of other cancers? Despite official reassurances, we still don't seem to be any closer to a definite answer. Scroll down for more ... Dangerous call? Opinion is divided on the safety of mobile phonesLast September, the Mobile Telecommunications and Health Research (MTHR) programme, which is funded jointly by the Government and the industry, concluded that mobile phones, base stations and ... More About: Phone , Cell Phone , Cell , Radiation
Autism Families with a High Incidence of Alcoholism
2008-03-01 23:08:00 RESULTSAhigh prevalence of alcoholism was reported in the167 family study population; 13.5% of the first degreerelatives and 13.6% of second degree adults were reportedto have alcoholism including, 6.6% of mothers,20.4% of fathers, 8.4% of grandmothers, and 27.5%of grandfathers (Table I). Men were significantly morelikely to have a history of alcoholism than women(20.3% vs. 6.6%) 2(1) = 74.1, p http://www.genetics.missouri.edu/Autism Al cholism.pdfFetal Alcohol Spectrum and Autism Spectrum Disorders © 2005 Teresa Kellerman, amended 2007 Section 1. Section 36-551, Arizona Revised Statutes: 36-551. Definitions 7. "Autism" means a condition characterized by severe disorders in communication and behavior resulting in limited ability to communicate, understand, learn and participate in social relationships. There are several types of Autism that together with Asperger’s Syndrome fall under the category of the Autism Spectrum Disorders (ASD). There are several types of disorders ... More About: High , Families , Alcoholism
fathers' ages were strongly associated with a diagnosis of schizophrenia or
2008-02-29 23:51:00 INCREASING PATERNAL AGE.THERE ARE TEN STUDIES FROM ALL OVER THE WORLD WITH THE SAME RESULT.April 12, 2001 Father's Age Linked to Risk of Schizophrenia By ERICA GOODE The risk of having a child with schizophrenia may increase with a father's advancing age, researchers reported yesterday.The researchers, who examined the relationship between the fathers' ages and schizophrenia among 87,907 Israelis born from 1964 through 1976, found that the older the father, the more likely he was to have a child who suffered from schizophrenia, a devastating mental illness.Men who were 45 through 49, for example, were twice as likely to have offspring with schizophrenia or a related disorder as were men under 25, the researchers found. The overall risk of having a child with the illness, however, remained small."The finding is a very strong association of schizophrenia risk and father's age," said Dr. Delores Malaspina, an associate professor of clinical psychiatry at the Columbia University Coll... More About: Fathers , Diagnosis , Ages
an affected first-born is seen most dramatically in the group of AGRE fathe
2008-02-29 03:43:00 The paternal age distribution of the AGRE fathers, whose first child is autistic differs significantly from that of the 'control' sample (P=0.005). A 2 goodness-of-fit test with 2 degrees of freedom was conducted using percents in the 'control' group age categories to calculate the expected values in the AGRE sample. The shift toward higher paternal ages in those with an affected first-born is seen most dramatically in the group of AGRE fathers who are 30–39 years inclusive, which is 54.7% of the distribution compared with the 41.9 % that is expected. We interpret this shifted age distribution to provide support for the recently reported finding by Reichenberg and co-workers that autism risk is associated with advancing paternal age.1: Mol Psychiatry. 2007 May;12(5):419-21. LinksPaternal age and autism are associated in a family-based sample.Cantor RM, Yoon JL, Furr J, Lajonchere CM.PMID: 17453057 [PubMed - indexed for MEDLINE] More About: Group , First Born
Autism Cure Impossible for Paternal Age Derived Problems
2008-02-29 01:23:00 Later Paternal Age Can Influence Neural Functioning Finally, we examined if paternal age was related to the risk for autism in our cohort. We found very strong effects of advancing paternal age on the risk for autism and related pervasive developmental disorders (Reichenberg et al., in press). Compared to the offspring of fathers aged 30 years or younger, the risk was tripled for offspring of fathers in their forties and was increased fivefold when paternal age was >50 years. Together, these studies provide strong and convergent support for the hypothesis that later paternal age can influence neural functioning. The translational animal model offers the opportunity to identify candidate genes and epigenetic mechanisms that may explain the association of cognitive functioning with advancing paternal age.Labels: advancing paternal age, autism, cognitive funcgtioning, neural functioning, schizophrenia More About: Autism , Problems , Impossible , Cure
T.J. Crow (1987) argued that psychosis is caused by a high rate of mutation
2008-02-29 00:48:00 T.J. Crow (1987) argued that psychosis is caused by a high rate of mutations occurring specifically in the course of gametogenisis of the male .The impression is that the fathers were relatively old too, their mean agebeing between 31 and 36 years. Allen et al. (1971) and Gillberg (1982)applied tentative reference groups, pointing at patient's fathers being 3-4years older than the control.When controlling for sex, social group, time of birth, and place ofbirth we found that the mean paternal age (see Table V) in the three diagnosticgroups was raised 0.94-2.05 years, but only statistically significant(p = .02) for the borderline childhood psychosis diagnostic group. Formothers (see Table IV) the respective figures varied between -0.06 and0.83 years and did not reach statistical significance. It is possible that earlierfindings of greater differences for mothers were influenced by lack of control of relevant confounders or was partly a consequence of raised paternalage (Hare & Moran,... More About: High , Rate
Government Concedes an Autism Caused by Vaccines Case
2008-02-28 03:55:00 David Kirby in the Huffington Post"The child's claim against the government -- that mercury-containing vaccines were the cause of her autism -- was supposed to be one of three "test cases" for the thimerosal-autism theory currently under consideration by a three-member panel of Special Masters, the presiding justices in Federal Claims Court. Keisler wrote that medical personnel at the HHS Division of Vaccine Injury Compensation (DVIC) had reviewed the case and "concluded that compensation is appropriate." The doctors conceded that the child was healthy and developing normally until her 18-month well-baby visit, when she received vaccinations against nine different diseases all at once (two contained thimerosal). Days later, the girl began spiraling downward into a cascade of illnesses and setbacks that, within months, presented as symptoms of autism, including: No response to verbal direction; loss of language skills; no eye contact; loss of "relatedness;" insomnia; incessant screa... More About: Government , Autism , Vaccines , Case
David Archuleta Imagine American Idol
More articles from this author:2008-02-27 06:38:00 WOW! video of performance More About: American Idol , American , David , Idol , Imagine 1, 2, 3, 4, 5, 6, 7 |
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