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Molecular Cell Biology (Free E-book)
2008-09-20 15:32:00 by James Darnell (Author), Paul Matsudaira (Author), Lawrence Zipursky (Author), Harvey Lodish (Author), Arnold Berk (Author), David Baltimore (Author)Hardcover: 1184 pagesPublisher: W. H. Freeman; 4th edition (October 1999)Language: EnglishISBN-10: 071673706XISBN-13: 978-0716737063See comments for download links.
Perfectionism: Are you on the downward spiral?
2008-04-21 12:51:00 Do you fear failure every time you do an experiment? Do you feel constantly stressed about obtaining poor results? Do you feel personally culpable when an experiment goes wrong? If you answered “yes” to any or all of these questions, you may be suffering from perfectionism. For a scientist, this is a particularly damaging trait that needs to ...
Control Your Lab Computers From Home
2008-04-14 08:20:00 If you have computers in the lab that you would like to access from home, this might be for you. LogMeIn.com offers a free remote desktop service that allows you to take control of a remote computer. Perfect if, while relaxing after dinner, you remember that you forgot to turn off the HPLC at work (yes, ...
PhD Research Project in Molecular and Cell Biology
2008-02-09 09:47:00 A graduate with experience and interest in cellular and molecular biology with (or waiting) at least second class honours degree or a higher degree second class honours with a Masters degree is required for this project based at the Skin Research Center, Share This
System Modeling in Cellular Biology : From Concepts to Nuts and Bolts
2008-01-21 18:58:00 System Modeling in Cellular Biology : From Concepts to Nuts and BoltsBook Publisher: The MIT Press (03 April, 2006)ISBN: 0262195488Book author: Zoltan Szallasi, Jörg Stelling, Vipul PeriwalBook Description:Research in systems biology requires the collaboration of researchers from diverse backgrounds, including biology, computer science, mathematics, statistics, physics, and biochemistry. These collaborations, necessary because of the enormous breadth of background needed for research in this field, can be hindered by differing understandings of the limitations and applicability of techniques and concerns from different disciplines. This comprehensive introduction and overview of system modeling in biology makes the relevant background material from all pertinent fields accessible to researchers with different backgrounds.DownloadPassword: ebooksatkoobeMirror1Mirror2
Nature Reviews Molecular Cell Biology
2008-01-19 20:06:00 Nature Reviews Molecular Cell Biology from its 1st issue to 2006 december 6years, 75 issues including highlights, reviews, perspectives, errata, supplemental videos, figuresDownload part1.rar of size 100 MBpart2.rar of size 100 MBpart3.rar of size 100 MBpart4.rar of size 100 MBpart5.rar of size 100 MBpart6.rar of size 100 MBpart7.rar of size 57.676 MBRar Password: Jinki
UK-Postdoctoral Research Associate in Molecular Cell Biology
2008-01-15 23:31:00 The University of Sheffield, UK Academic Unit of Cell Biology, School of Medicine and Biomedical Sciences, open a Postdoctoral positions. The project within the Laboratory of Molecular Cell Biology is in collaboration with the Vascular Science Section at Imperial College and funded by the British Heart Foundation, and will involve characterisation of a recently identified inflammatory regulator and focus on signaling crosstalk in vascular disease. Applicants should have an honors degree (or equivalent experience) and hold a PhD in Molecular or Cell Biology. The position is available from 1 April 2008 for 36 months. The position will be in the Academic Unit of Cell Biology in the Section of Infection, Immunity and Inflammation, with 20 faculty members and 73 Students. (more…) Share This Tags: biomedical science, cell biology, medicine, molecular biology, molecular cell biolog-y, postdoctoral, uk
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Australia-PhD Scholarships in Cancer Cell Biology
2008-01-13 22:44:00 University of Sidney, Australia Cancer Cell Invasion and Metastasis should be the research subject of this full time postgraduate scholarships. Provided by the University of Sidney, this scholarships is available for a suitably qualified candidate with a good honours or higher degree in science to undertake research studies leading to a PhD in cancer cell biology. The project extends our recent discoveries in cancer cell migration mechanisms to biomolecular, clinical investigations. Live-cell 4D imaging, in vivo biosensor tracking and microarray techniques will be used to characterize cancer cell behaviour. (more…) Share This Tags: australia, biological science, biomolecular, cancer, cancer cell, phd, Postgraduate, research
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Clock Genes and Migration
2008-01-10 12:57:00 Coturnix has the goods on a handful of studies on the gene Cry2 in Monarch Butterflies: The spatial and temporal patterns of expression make Cry2 the most serious candidate for the connection between the clock and the Sun-compass orientation mechanism. Much work, both at the molecular and at higher levels of organization needs to be done ...
By: Migrations
History of Cell Biology
2007-11-05 15:09:00 The cell theory, or cell doctrine, states that all organisms are composed of similar units of organization, called cells. The concept was formally articulated in 1839 by Schleiden & Schwann and has remained as the foundation of modern biology. The idea predates other great paradigms of biology including Darwin?s theory of evolution (1859), Mendel?s laws ...
[UK] PhD Studentship in Cell Biology, Open University
2007-10-30 23:16:00 Full-time PhD Studentship in Cell Biology Department of Life Sciences, Faculty of Science (Based in Milton Keynes)Three years from 1 January 2008The response of human brain endothelium and astrocytes to vasoactive mediators, funded by the Migraine Trust.The aim of the project is to determine how brain microvascular endothelial cells can modulate local blood flow, and contribute to the electrophysiological disturbances that underlie migraine aura. The work will use tissue culture systems to investigate the mediators released by brain endothelium. The effects of endothelin, nitric oxide and eicosanoids on the permeability of endothelium and the activation of astrocytes, will be examined in association with drugs that may be used in treating migraine.You should have a good honours degree in a biological or biomedical science, emphasis molecular cell biology.Informal enquiries may be made to Prof. David Male: email D.K.Male[ at ]open.ac.uk; telephone 01908 659226.For detailed informatio...
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Printing Living Cells
2007-10-14 19:37:00 Via ScienceFriday on NPR this past Friday (10/12), scientist Paul Calvert describes efforts to convert the common home office technology of inkjet printing to manipulate living cells: In this segment, we’ll look at new research into using inkjet technology to build artificial tissues. Writing in the journal Science, Paul Calvert describes efforts to convert the common ...
By: Migrations
Know Your Cell Structures
2007-10-08 21:50:00 The cell’s skeleton, or cytoskeleton, is involved in just about every major activity that cells perform, and the actin cytoskeleton in particular. This month’s Nature Cell Biology has a review on the actin ‘microfilaments’ and their roles in over 15 cell activities, that nicely underscores the diversity of functions one component can be co-opted ...
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Touchstone of Life: Disappointing Book on Information and the Foundations o
2007-09-12 19:36:00 Trying to find good books to review on cell biology just isn’t easy, but I’ve been looking. Werner Loewenstein had an interestingly titled one published in 1999, that I thought sounded interesting: The Touchstone of Life: Molecular Information, Cell Communication, and the Foundations of Life. An intriguing combination of topics, I thought - ...
By: Migrations
?Spring Theory? - Approaching Cell Biology with Physics
2007-09-02 18:14:00 Brief mention: An interesting news feature on the burgeoning collaborations between biology and physics, with a catchy title: Physics in the cell: Spring theory. In the cell there?s no eye-soothing white space to separate things. Water molecules are a constant omnidirectional hailstorm, van der Waals forces glue things together and viscosity rules. Within this molecular ...
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Bacterial Cytoskeleton
2007-07-27 22:09:00 [Figure 1 from Shih and Rothfield (2006); click on image to enlarge] Recently, Alex had asked for a mention of the bacterial cytoskeleton, which does deserve mention. As Shih and Rothfield describe, the amino acid sequences of eukaryotic and bacterial cytoskeletal monomers bear minimal resemblance to one another. Their 3-dimensional structures, however, bear striking ...
By: Migrations
Centrosome Structure and Duplication
2007-07-13 14:45:00 Following my review of the major eukaryotic cytoskeleton components, and microtubules in particular… A pair of centrioles is shown, each with ninefold symmetry owing to the nine triplet microtubules. Each centriole has pericentriolar material that nucleates microtubules around the ends closest to one another. Only the maternal centriole has two sets of extra appendages, distal and ...
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Other Cell Biology Tutorials
2007-07-11 16:33:00 In addition to the few basic concept posts I’ve assembled (more will come, with time), there are a few very good ones from Bora of A Blog Around the Clock: Cell Structure Cell-Cell Interactions From One Cell To Two: Cell Division and DNA Replication From Two Cells To Many: Cell Differentiation and Embryonic Development Biology and the Scientific ...
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Visualizing the Stages of Mitosis
2007-07-10 01:45:00 Via a Hungarian Polish science blog that kindly links to me often enough, I came across a great YouTube clip describing the stages of mitosis with beautiful graphics. While I can’t understand Hungarian Polish at all, Miggawki looks like a very nice science blog, with interests rather comparable to my own. The videoclip ...
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Chemotaxis of a Single Cell Towards cAMP
2007-06-30 22:56:00 Time-lapse video microscopy (DIC optics, 60X objective) of a single cell (Dictyostelium, I think) moving toward a micropipette containing the chemoattractant cAMP. Note that the cell changes direction in response to movement of the micropipette by extending a new pseudopod in the direction of the pipette tip.
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Regulation by GEFs
2007-06-20 23:17:00 In the same vein as my recent post on kinase structures and autoinhibition of multimodular signaling proteins, last week’s Nature had a post on Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors (Yeh et al., 2007). Here, instead of kinases as the signaling regulators inside the cell, we’re talking about a class ...
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Kinase Structures and Autoinhibition
2007-06-18 16:20:00 As more structures are being solved for multimodular signaling proteins, the regulatory kinetics (on, off, and everything in between) is coming into greater clarity. For instance, the recently solved structural basis for allosteric autoinhibition of focal adhesion kinase (FAK), along with the ZAP-70 tyrosine kinase, and the protypical tyrosine kinase Src. As with ...
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Stem Cell Reprogramming Questions
2007-06-13 16:19:00 I finally got to reading the papers on the recent stem cell advances, and they do a nice job of studying the epigenetic, morphological, and proliferative characteristics of the induced pluripotent stem (iPS) cells. They four factors that were pinpointed for this reprogramming technique include the proteins Oct3/4, Sox2, c-Myc, and Klf4, with Nanog ...
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Cellular Alchemy: Transforming into Stem Cells
2007-06-08 12:27:00 Wow. This is a big week for stem cell research. There’s so much talk going on about it though, that I haven’t been able to keep up with (I haven’t even gotten around to reading the papers yet), but genetically manipulating fibroblasts to become ESC(embryonic stem cell)-like sort of sounds like alchemy in ...
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Systems Biology: It Sounds Too Holistic for Me
2007-06-05 17:42:00 According to the NY Academy of Sciences, systems biology “aims to build data-driven numerical representations of biological systems.” In describing this burgeoning area of biology, they use words like “big picture” an awful lot - they might as well say holistic - bah humbug to that! (I’m just kidding - putting biochemistry and ...
By: Migrations
Biophysics Papers
2007-06-01 15:01:00 Though I work alongside some biophysics researchers, I’m not quite sure how to put papers on cellular biophysics into the proper context. Such papers are insightful, interesting, and provide great background for me in studying other aspects of cell biology, but I’m just not familiar enough with the physics- and engineering-minded approaches. So I’m just ...
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Differential Purification of the Pseudopodium
2007-05-25 16:43:00 In an interesting paper in last week’s PNAS, Yingchun Wang and colleagues have done something interesting: dissected apart the pseudopodium from the remainder of the cell body in chemotactic cells, for proteomic analysis. This is extremely useful, as it may help to characterize the polarized spatial distributions of multiple signaling networks. And there’s ...
By: Migrations
Hypoxia: Selecting for Maligant Phenotypes in Cancers
2007-05-02 19:13:00 One paper that peripherally caught my interest last week was a review by Richard Sullivan and Charles Graham, on Hypoxia-driven selection of the metastatic phenotype. Hypoxia - the deprivation of oxygen to cells, in this case, cells at the center of a tumor mass - both kills a lot of tumor cells, as well ...
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Maintaining Germinal Niches in the Adult Brain
2007-04-19 17:57:00 Sometimes, it’s useful to revisit reviews, and today’s a good day to describe what’s known about how neural progenitor cells maintain themselves in the adult brain. Neural progenitors afford the brain with its limited regenerative capacity - a capacity that medical doctors and scientists are trying to exploit, for treating damaged and degenerating components ...
By: Migrations
Molecular Cell Biology Video
2007-02-22 11:45:02 Okay, this came out a while ago, but it’s a great video, and I’m otherwise occupied today and possibly tomorrow. This video has commentary, to help you know what you’re looking at, with the commentary being laid over the original Cellular Visions: The Inner Life of a Cell. Of course it’s an oversimplification, with way too much open space inside the cell, only a couple copies of proteins where there are really thousands, a few dozen types proteins where there are thousands, etc. But it gives you a nice conceptual view. Enjoy.
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Molecular Cell Biology in a Changing World
2006-08-15 19:42:05 Scanning around the journals of interest to me this Monday morning, I found a couple article series in Nature Reviews Molecular Cell Biology that nicely encapsulates the two areas that research on cell migration, and cell biology in general, are impacting our world. The first is the fundamental advances in understanding animal physiology, with the series on Developmental Cell Biology. Unfortunately, it looks as though they only have about a dozen reviews in this series… I say only, because there’s so much fascinating work being done in this area: relating to evo-devo, tissue morphogenesis and vasculogenesis, tissue architecture and engineering and other advancing areas that fundamentally advance our understanding of the body on the cellular level. The other is the flip-side of the physiological question - it’s the Molecular Mechanisms of Disease. This series is much newer, but has the potential to be just as broad of a series. One obvious focus is on the mechani...
By: Migrations
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