HIV Gene Therapy Trial Promising
2009-02-16 15:06:00 From BBC News | Science & Environment | UK Edition: One of the first attempts to use gene therapy to treat HIV has produced promising results in clinical trials. When the therapy was tested on 74 patients, it was shown to be safe and appeared to reduce the effect of the virus on
New Treatment and Prophylaxis of Baldness by Gene Therapy
2008-11-11 09:44:00 Baldness is lacking of hair from where it normally grows. There are around 100000 hair follicles on head. Hair loss about 50 to 100 per day is measured as normal. Approximately 50% of people...
GENE THERAPY RESTORES VISION
2008-05-07 11:50:00 Source: Hindustan times 29th April, 2008Persons with congenital retinal disease get partial sight with experimental method in the USAn experimental gene therapy has helped restore partial vision to persons with congenial retinal disease, according to studies published Sunday in a breakthrough which provides hope for treating various eye illnesses.In one study, clinical trials showed success on 3 young adults at children?s hospital of the Philadelphia who suffered from a rare and as yet incurable form of congenital blindness.The retinal degenerations include leber congenital amaurosis, or LCA, a group of diseases that affect light receptors in the retina beginning in early childhood and often causing total blindness in patients in their twenties or thirties.?This result is important for the enter field of gene therapy?. study leader Katherine High was quoted as saying in a new England Journal of Medicine whose website reported the findings by a collection of internati...
News : Gene therapy improves sight in near-blind patients
2008-04-28 17:25:00 By Deena Beasley and Ben Hirschler LOS ANGELES/LONDON (Reuters) - Gene therapy for a rare type of inherited blindness has improved the vision of four patients who tried it, boosting hopes for the troubled field of gene repair technology, scientists said on Sunday. Two separate teams of doctors reported successes in using gene therapy to treat Leber congenital amaurosis, or LCA. LCA damages light receptors in the retina. It usually begins affecting sight in early childhood and causes total blindness by the time a patient is 30. There is no treatment. Both teams used a common cold virus to deliver a normal version of one damaged gene that causes the disease, called RPE65, directly into the eyes of patients. Although both trials were only testing for safety, patients reported they could see a little better afterwards, the researchers told a meeting of eye specialists in Florida and also reported in the New England Journal of Medicine. Dr. Katherine H...
Gene therapy cures Leber Congenital Amaurosis
2008-04-28 00:00:00 In a medical breakthrough, Foundation Fighting Blindness has achieved a critical milestone in curing a form of childhood blindness: Leber Congenital Amaurosis. The three patients who were given the treatment have better eyesight now.
Gene Glitches May Increase Life Expectancy
2008-04-16 06:36:00 Genetic mutations may hold the key to longer life say scientists at the Institute for Aging Research at Albert Einstein College of Medicine in New York.
Gene Therapy Usage in Treating Adenosine Deaminase (ADA) Deficiency
2008-02-21 21:51:00 Gene therapy is a method of correction treatment for damaged gene for inherited disease sufferer. This method first used in treatment for lacks of the immune response genetic disease (genetic immunodeficiency) which is known as lacking of Adenosine Deaminase (ADA) or ADA(-). This ADA enzyme is needed to complete the formation and development of body immune system.ADA(-) disease attacks new born baby and causes death. The baby is not able to produce antibody system and complete immunization. They easily seize diseases such tetanus, diphtheria, breathing infection disease, measles, and pneumonia. Some patients might have no antibody and immune system at all. This is known as severe combined immunodeficiency - SCID. Usually, children who have disease ADA(-) SCID experience recurring virus, fungus, and bacteria infection and have high risk of early cancer infection.The best treatment method for this disease is gene therapy. With this method normal ADA gene from donor is admitted into bo...
By: My Health
Gene Therapy For Hearing Loss
2008-02-07 15:01:00 Human hair cells. (Credit: Image courtesy of University of Virginia Health System)A novel gene therapy approach has been developed by the scientists in University of Virgina Health System to treat the patients with genetic or acquired hearing loss.The research has focused on a gene called KCNQ4. It is said that this gene is responsible for genetic hearing loss in human when it get mutated. According to the resources, Dr. Jeffrey Holt, associate professor of neuroscience and otolaryngology at UVa, and his research team, including Dr. Bradley Kesser, an assistant professor of otolaryngology, have engineered a correct version of this gene. Then they have transferred these modified genes in to hair cells obtained from inner ears of people having genetic hearing loss, by using a gene therapy delivery system, developed by this team"Our results show that gene therapy reagents are effective in human inner ear tissue” says Dr. Holt.Hair cells are special kind of cells that lines the cochle...
Gene therapy 'corrects fragile X'
2007-12-20 14:32:00 From BBC News | Science/Nature | UK Edition: Gene therapy has been used to alleviate symptoms of a condition which is a leading cause of inherited learning difficulties and autism. There is currently no treatment for fragile X syndrome, also linked to epilepsy and abnormal b
Mesothelioma gene therapy
2007-12-02 01:16:00 Presently, new approaches for malignant mesothelioma treatments are being put to test. Traditional mesothelioma treatments are usually combined or something new is being introduced.
Potential Gene Therapy Treatment for Parkinson?s
2007-11-22 00:13:00 . . . and it’s completely ethical! From the story in the Telegraph: Evidence that a breakthrough has been achieved in gene therapy for serious brain diseases has come with the release of the hard evidence that it works in Parkinson’s disease. Patients were given injections of billions of copies of genetically altered viruses into parts ...
By: Choose Life!
Sudden Death Puts Gene Therapy In Spotlight
2007-10-01 11:03:00 Jolee Mohr aged 36 may have died due to a controversial gene therapy study to help cure her arthritis. The cause of death is still being investigated.
Vectors: the ongoing dilemma in effective gene therapy
2007-09-18 04:40:00 The unfortunate recent death of Jolee Mohr on July 24th 2007, aged 36, who was participating in a gene therapy trial, has highlighted the disparity between the amount of new gene purpose discoveries, and the creation of effective gene therapies that can utilise this knowledge. This is not to say this specialised field is being ignored quite the opposite, but rather there has been a lower
By: The IWH Inquirer
Toward safer gene therapy?
2007-09-09 09:40:00 From ZDnet: September 8th, 2007 Toward safer gene therapy? Posted by Roland Piquepaille @ 9:46 am Gene therapy has been used in more than 1,000 clinical trials during the last 20 years. But the U.S. Food and Drug Administration (FDA) has never approved a single application. The reason is simple: the former trials were using viruses to deliver genes ...
Gene Therapy Reduces Amyloid Plaques In Mice With Model Of Alzheimer Diseas
2007-08-29 04:56:00 A new gene therapy technique has been shown to reduce the amount of amyloid-beta protein (which forms the plaques found in the brains of people with Alzheimer's disease) in the brains of mice. In a paper published this week in the open access medical journal PLoS Medicine Matthew Hemming, Dennis Selkoe and colleagues from Harvard Medical School generated a secreted form of neprilysin, a protease that can break down amyloid-beta protein, and used primary fibroblasts to introduce this soluble protease into the brains of mice who had advanced plaque deposition.The pathologic hallmarks of Alzheimer disease are extracellular plaques of amyloid-beta protein and intraneuronal neurofibrillary tangles of tau protein, both of which accumulate in the regions of the brain that mediate memory and thought. Current treatments for Alzheimer disease affect only the symptoms. Ultimately it is to be hoped that it would be possible to develop disease-modifying interventions that would lower the produc...
Gene Therapy ? The new frontier in the fight against cancer!
2007-08-06 18:14:00 Scientists in the United Kingdom are using gene therapy, as a new approach to treat cancer. They are using genetically modified Human Herpes Virus (of the family Herpesviridae) to infect tumor cells and to destroy them and by doing so they are able to harness the destructive power of this virus (which usually causes infection in humans, marked by painful, watery blisters in the skin or mucous membranes or on the genitals) to seek out and destroy cancer. The genetically modified Herpes Virus not only destroys tumor cells, but also produces biomarkers that help our immune system to identify tumor cells. This new approach has been effective in animals and a handful of cancer patients in clinical trials. Scientists believe that gene therapy could become a radical new approach to fight cancer, in future. This news video from BBC News throws more light on this ground-breaking research.
Viral Vectors for Gene Therapy: Methods and Protocols
2007-07-29 16:39:00 Edited by Curtis A. Machida (Humana Press) Contents: 1 Use of the Herpes Simplex Viral Genome to Construct Gene Therapy Vectors (Edward A. Burton, Shaohua Huang, William F. Goins, and Joseph C. Glorioso) 2 Construction of Multiply Disabled Herpes Simplex Viral Vectors for Gene Delivery to the Nervous System (Caroline E. Lilley and Robert S. Coffin) 3 Improved HSV-1 Amplicon Packaging System Using ICP27-Deleted, Oversized HSV-1 BAC DNA (Yoshinaga Saeki, Xandra O. Breakefield, and E. Antonio Chiocca) 4 Herpes Simplex Amplicon Vectors (Charles J. Link, Nicholas N. Vahanian, and Suming Wang) 5 Strategies to Adapt Adenoviral Vectors for Targeted Delivery (Catherine R. O?Riordan, Antonius Song, and Julia Lanciotti) 6 Use of Recombinant Adenovirus for Gene Transfer into the Rat Brain: Evaluation of Gene Transfer Efficiency, Toxicity, and Inflammatory and Immune Reactions (Andres Hurtado-Lorenzo, Anne David, Clare Thomas, Maria G. Castro, and Pedro R. Lowenstein) 7 Generation of Adenovirus ...
Patient Death Sets Back Gene Therapy Study
2007-07-28 15:48:00 This week, a patient undergoing a gene therapy study in Seattle died from complications of the procedure, causing the government to suspend the study. The patient’s cause of death was not revealed. They were undergoing therapy for advanced arthritis. This is the third death since 1999 in the gene therapy field. Scientists do not know if the deaths are resulting from the viruses they are using to inject new genes into patients. About 28 other gene therapy studies are also using this virus called adeno-associated virus or AAV. About 100 people had enrolled in Targeted Genetics Corp. without problems. The patient who died became sick after the second injection of the therapy directly into an arthritic joint. Other procedures used to help treat arthritis include drugs that block joint inflammation, but gene therapy is a rapidly growing approach. In 1999, an 18-year-old male died in his fourth day of treatment at the University of Pennsylvania. The only disease ever actually cured with...
Gene Therapy For Pancreatic Cancer
2007-07-10 08:07:00 A molecularly engineered therapy selectively embeds a gene in pancreatic cancer that shrinks or eradicates tumors, inhibits metastasis, and prolongs survival with virtually no toxicity, researchers from The University of Texas M. D. Anderson Cancer Center report in the July 9 edition of Cancer Cell. “This vehicle, or vector, is so targeted and robust in its ...
By: Cancer war
Mesothelioma faq (gene therapy, immunotherapy, VATS)
2007-07-06 15:12:00 How does gene therapy work? Gene therapy is a procedure for treatment of mesothelioma cancers by altering the expression of a person’s genes in line a therapeutic goal. The objective and aim of gene therapy is centred on rectifying disease at DNA level and to compensate for the abnormal genes.
Gene therapy can cure heart
2007-07-05 13:28:00 Canadian researchers to a 52-year-old heart attack patients using gene therapy. The patients with severe coronary artery blocked, and heart surgery unsuitable for streaming, The doctors decided to patients with lesions injection of a DNA (deoxyribonucleic acid). It is coming out of the hospital itself, is a naturally occurring human protein that promotes vascular regeneration, it is also referred to as endometrial vascular growth factor. Currently, the patient has not appeared abnormal. Gene therapy using human heart in the world also is the first time. If successful treatment, some patients with heart disease would be possible through injecting DNA from the disease problems. source:China TCM web-China
Gene therapy awakens the brain despite blindness from birth
2007-06-26 05:47:00 Researchers at the University of Pennsylvania have demonstrated that gene therapy used to restore retinal activity to the blind also restores function to the brain?s visual center, a critical component of seeing. The multi-institutional study led by Geoffrey K. Aguirre, assistant professor of neurology in Penn’s School of Medicine, shows that gene therapy can improve ...
Gene Therapy Delivery Of Nerve Growth Factors Reverses Erectile Dysfunction
2007-06-04 15:00:00 Rats with erectile dysfunction that were injected with a gene therapy vector containing either of two nerve growth factors were able to regain normal function after four weeks, according to a new study. Popularity: 3% [?] Read more at silkboard
Pancreatic cancer ? outlook: gene therapy
2007-05-08 08:05:00 Abstract Gene therapy offers an elegant alternative to toxic chemotherapy regimens, mostly without severe side effects. Cancer gene therapy was among the first applications. Following the enthusiasm in the early nineties, a more rationale view is the recent way to look at it. This tutorial review looks upon the tools of gene therapy and the principle ...
Nanoparticle gene therapy studied
2007-04-18 19:01:00 HOUSTON, April 18: U.S. medical researchers have delivered a cancer-suppressing gene into tumors of lung cancer patients using a lipid nanoparticle.
By: newkerala.com
Ultrathin Films Deliver DNA as Possible Gene Therapy Tool
2007-03-26 18:01:00 From PhysOrg.com - latest science and technology news: Gene therapy - the idea of using genetic instructions rather than drugs t... |
|
 |
|
 |
