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'Smart Bomb' Nanoparticle Strategy Impacts Metastasis
2008-07-08 15:52:00 From ScienceDaily: Latest Science News: A new treatment strategy using molecular "smart bombs" to target metastasis with anti-cancer drugs leads to good results using significantly lower doses of toxic chemotherapy, with less collateral damage to surrounding tissue. By designing
Common Therapy for Prostate Cancer May Promote Metastasis
2007-11-14 16:12:00 A study published in the journal Cancer Research last month suggests that the principle treatment for advanced prostate cancer may actually encourage prostate cancer cells to metastasize [1]. Researchers at The Johns Hopkins University School of Medicine focused on a gene called Nestin, which encodes an intermediate filament protein. Intermediate filaments are cytoskeletal or scaffolding ...
By: Highlight HEALTH
Weinberg on Metastasis: ?The Last Frontier in Cancer Research?
2007-10-16 12:05:00 Via ScienceFriday on NPR this past Friday (10/12), a Cancer Update with Robert Weinberg: In this segment, Ira talks with cancer researcher Robert Weinberg about what he calls the last frontier of cancer research. Weinberg has been instrumental in studies of oncogenes, genes that can spark the rapid cell multiplication associated with cancerous tumors. Now, in ...
By: Migrations
Hepatic arterial chemotherapy in the treatment of liver metastasis of gastr
2007-10-10 09:44:00 According to the Japanese academics, and when no liver metastasis of gastric cancer, surgical resection, sustained by hepatic artery infusion chemotherapy can produce good results. Osaka National Hospital Dr Y Hasuike and his colleagues on two cases for a number of liver metastasis (five or more) in patients with gastric cancer sustained hepatic arterial infusion (CHAI) large dose 5 - 5-fluorouracil (5-FU) chemotherapy, and then to assess its efficacy. 5-FU through the hepatic artery to a gram / day dose administration sustained three days, stopping day, to repeat a course. In two cases, one cases of gastric cancer is Borrmann two, aged 67, in the whole stomach after 11 months there have been a number of hepatic metastases, the largest diameter of 3.5 cm. Researchers in one month for its two courses of CHAI, two middle intermittent treatment four days. Then, 1.5 g / week dose hepatic arterial infusion (HAI) 5-FU twice. The results found that CHAI three months after treatment, tumor ...
Explaining Metastasis
2007-10-04 19:28:00 Cancer kills. I know, big surprise. But the average layperson probably have no clue that 90% of cancer deaths are associated with metastasis, or tumor dissemination, and even less people are aware of how metastasis occurs. At the cellular level metastasis is a very inefficient process; large tumours can shed millions of cells ...
By: Migrations
Metastasis of Breast Cancer (Cancer Metastasis - Biology and Treatment) (Ca
2007-08-31 20:48:00 # Publisher: Springer; 1 edition (August 8, 2007)# Language: English# ISBN-10: 1402058667# ISBN-13: 978-1402058660 Product DescriptionMetastasis (spread of cancer in the body) is the main cause of death for patients with breast cancer, the leading female tumour in the industrialised countries and developing countries alike. The biology and treatment of breast cancer metastasis remains an active area of scientific and clinical investigation.Written by experts in the subject area, the book has covered a broad range of topics in the metastasis of breast cancer, from genetics, biology to clinical management. Main topics include genetic control, biology, growth factors, cell adhesion, cell motility and invasion, natures of bone metastasis, sentinel node therapies, hormonal links, new biomarkers and detection of micrometastasis, and diagnosis The book also covers the current treatment options including surgical management, chemotherapy and hormonal therapies. This timely book provides the...
Dc immunotherapy is highly effective for the inhibition of tumor metastasis
2007-04-21 10:04:00 Abstract Dendritic cell (DC)-based immunotherapy has not been as effective as expected in most solid tumors even in the murine model, particularly in renal cell carcinoma (RCC). Our investigation was initiated to identify what causes the limitations of DC-based immunotherapy in solid RCC. We have investigated immunosuppressive factors from tumors and their effects on DC migration, ...
Researchers Identify New Target for Blocking Cancer Cell Metastasis
2007-04-02 16:05:00 Last week, the Van Andel Institute announced that its researchers have identified a protein involved in cancer cell metastasis, called DIP. DIP binds to and inhibits the activity of mDia2, a protein that works to control tumor cell metastasis, or the development of secondary tumors away from the primary cancer site. When DIP binds to mDia2, it causes the affected cells to change shape and bubble, or bleb. This cell blebbing inhibits the control mDia2 has over tumor cell metastasis and may lead to development of secondary tumors. If researchers can find a compound that will inhibit DIP, they believe it could prevent cancer cells from metastasizing, vastly improving the survivability of many forms of cancer.
Spemann Organizer Gene Promotion of Metastasis
2006-12-12 16:14:01 One popular area of research in cell migration in vivo is the role of homeobox transcription factors in promoting metastasis and malignancy, when overactive in adult animals. In this week’s Proceedings of the National Academies of Science, Robert Weinberg’s group has another paper to contribute to this story: The Spemann organizer gene, Goosecoid, promotes tumor metastasis. Those following the area of Evo-Devo, or at least those that have read Carroll’s Endless Forms Most Beautiful, will remember that the Spemann’s organizer was originally identified as a cluster of cells capable of inducing and directing dramatic changes in the developing embryo. It was later identified that the unique properties of Spemann’s organizer were determined by transcription factors, which were categorized as homeobox genes. Broad analogies between migrating tumor cells and migrating subpopulations of cells during embryonic development suggest that these processes have ...
By: Migrations
Mathematical Modeling of Metastasis and Selection in Tumor M
2006-12-05 22:00:02 There’s a paper in last week’s issue of Cell that takes aim at alternative models of metastasis from a computational point of view that I’d like to mention briefly. In Tumor Morphology and Phenotypic Evolution Driven by Selective Pressure from the Microenvironment, Anderson et al. examine a list of variables that could impact cancer cell invasiveness. Cell is accepting comments, and Keith at Omics! Omics! has a brief post on the paper as well. Specifically, Anderson and colleagues interesting findings (from the abstract): Unexpectedly, the model simulations predict that harsh tumor microenvironment conditions (e.g., hypoxia, heterogenous extracellular matrix) exert a dramatic selective force on the tumor, which grows as an invasive mass with fingering margins, dominated by a few clones with aggressive traits. In contrast, mild microenvironment conditions (e.g., normoxia, homogeneous matrix) allow clones with similar aggressive traits to coexist with less aggressi...
By: Migrations
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