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IVF ART A negative correlation identified between paternal age and art outc
2007-12-15 01:42:00 doi:10.1016/j.fertnstert.2007.0-7.368 Copyright © 2007 American Society for Reproductive Medicine Published by Elsevier Inc. Poster presentations A negative correlation identified between paternal age and art outcome: is there a male biological clock ticking? M. Lunaa, J. Barritta, N. Bar-Chamaa, A.B. Coppermana, T. Mukherjeea and L. Grunfelda aReproductive Endocrinology and Infertility, Reproductive Medicine Associates of New York; Mount Sinai School of Medicine, New York, NY P-13. Available online 9 September 2007. Supported by: None. http://www.slate.com/id/2109131-/Yet nagging concerns have prompted a flurry of new studies, a number of which were presented at the ASRM conference. Most are disturbing in some way; none seem conclusive; a few are contradictory. In what will probably emerge as one of the more significant, Mary Croughan of the University of California, San Francisco, has received that rare thing in this field—federal funding—to track the development of IVF ...
50x365 #59: Paternal Grandmother
2007-11-19 20:16:00 I've got letters I'd like to use, I said, shuffling tiles around on my rack.Mm-hmm, she said. Such as?I have an F, C, and K. Slang is legal, I said.You can't use them, she said.She followed that with the word ?stickle? for nearly 80 points.I am a participant in x365 and NaBloPoMo. Check out the upper right sidebar and vote for me in the 2008 Blogger's Choice Awards.
Paternal Age and Genetic Disorders Has Been Hidden From the Public For Over
2007-11-16 02:38:00 Passing this information to others person to person is the only way encourage earlier fathering of babies.
J Pediatr. 1975 Older paternal age and fresh gene mutation: data on additio
2007-11-15 22:50:00 Older paternal age and genetic disorders in offspring an old story that has been suppressed. Older is over 32 and up! 23-30 is the best age to father babies for their health.All: 1Review: 0Click to change filter selection through MyNCBI.1: J Pediatr. 1975 Jan;86(1):84-8.LinksOlder paternal age and fresh gene mutation: data on additional disorders.Jones KL, Smith DW, Harvey MA, Hall BD, Quan L.Older paternal age has previously been documented as a factor in sporadic fresh mutational cases of several autosomal dominant disorders. In this collaborative study, an older mean paternal age has been documented in sporadic cases of at least five additional dominantly inheritable disorders; the basal cell nevus syndrome, the Waardenburg syndrome, the Crouzon syndrome, the oculo-dental-digital sysdrome, and the Treacher-Collins syndrome. It was also found to be a factor in acrodysostosis and progeria, suggesting a fresh mutant gene etiology for these two conditions in which virtually all case...
THE KEY TO THE AUTISM EPIDEMIC IS THE RISING AVERAGE PATERNAL AGE,
2007-11-15 18:07:00 This is not to deny vaccinations and family history as causes of autism etc. but older paternal age is a sure cause of health problems for children.
Pulls the paternal aunt to approve 栢 The iris makes the mother value four
2007-11-10 11:28:00 Chart: Pulls the paternal aunt to reprimand some people randomly to make the news (material picture)Yesterday had the report to refer open 栢 The iris because conspires to resurface makes money, recently frequently went to town, stays behind loves in the home, moreover stopped feeding the person milk. Also said 栢 The iris this act is pulled paternal grandmother the paternal aunt really is the disaffection. Yesterday pulled the paternal aunt and 栢 The iris accepts Zha Hsiaohsin together the broadcasting station program telephone visit, 栢 The iris expressed this report really too bored, most is bored is refers to her to feed ten times of people milks every day. 栢 The iris acknowledged already has not fed the person milk, mainly is because of Gu Naihao the pain, on in addition encircles the measurement, causes her body to change is not balanced, therefore certainly must stop feeding the person milk.栢 The iris indicated that, paternal grandmother saw the report, compares her ...
Radical Health Proposal In England-Libertarian Paternalism!
2007-10-23 14:53:00 Is it time for radical new ideas about health? Is it time for government to take a more active role ensuring the health of its citizens? Professor Julian Le Grand, chair of Health England, told an audience about his new ideas to take a dramatic attack in dealing with health problems in England. His nation ...
50x365 #21: Paternal Grandfather
2007-10-12 16:32:00 You always poured two fingers, and because you kept the rye in the cupboard above the electric refrigerator, its heat made the ice cubes crack and sizzle. By the pull of your eyebrows, it was important to pour a full two fingers. I promised myself: I would always pour three.I am a participant in x365.
It is very possible that Paternal Age is the Major Predictor for autism---
2007-10-11 00:20:00 Harry Fisch is the author of The Male Biological Clock, The Patient's Guide to Vasectomy Reversal, The Patient's Guide to Varicocele Repair and Managing The Vasectomy Patient. He is one of the nation's leaders in the diagnosis and treatment of male infertility and microsurgical vasectomy reversal. Dr. Fisch is director of the Male Reproductive Center and directs urologic microsurgery in the Department of Urology at Columbia University Medical Center of New York Presbyterian Hospital in New York City. He is also professor of clinical urology at Columbia University, where he was recently named Teacher of the Year in his department.For over fifteen years, Dr. Fisch has focused his research, practice, and surgery on male infertility and reproduction.From the Psychology Today article:"Everybody was familiar with the concept of women's biological clock, but when we introduced 'male' to the equation, the reaction was 'What are you talking about? Men can have children at any age,'" ...
Paternalismo Corporativo
2007-10-09 21:18:00 “Onde quer que voc veja um negcio de sucesso, pode acreditar que ali houve, um dia, uma deciso corajosa.” (Peter Drucker) O fenmeno observado geralmente em pequenas empresas. Um funcionrio recm-admitido, ao trmino de sua primeira semana de trabalho, vai ao encontro do diretor. Adentra a sala meio cabisbaixo, trazendo nas mos contas de luz ...
There are many, many disorders attributed to the Paternal Age Effect- Apert
2007-10-06 23:57:00 1: Glaser RL et al. The paternal-age effect in Ap...[PMID: 12900791]-2003 OctTI-The paternal-age effect in Apert syndrome is due, in part, to the increased frequency of mutations in sperm.PG-939-47AB-A paternal-age effect and the exclusive paternal origin of mutations have been reported in Apert syndrome (AS). As the incidence of sporadic AS births increases exponentially with paternal age, we hypothesized that the frequency of AS mutations in sperm would also increase. To determine the frequency of two common FGFR2 mutations in AS, we developed allele-specific peptide nucleic acid-PCR assays. Analyzing sperm DNA from 148 men, age 21-80 years, we showed that the number of sperm with mutations increased in the oldest age groups among men who did not have a child with AS. These older men were also more likely to have both mutations in their sperm. However, this age-related increase in mutation frequency was not sufficient to explain the AS-birth frequency. In contrast, the mutation fr...
Why is the Paternal Age Effect Not Taught?
2007-10-06 23:19:00 Paternal age effectFrom Wikipedia, the free encyclopedia• Learn more about using Wikipedia for research •Jump to: navigation, searchThe paternal age effect describes the influence that a father's age has on the chances of conferring a genetic defect to his offspring. Generally, older men have a greater probability of fathering children with a genetic defect than younger men do.[citation needed] This is seen as likely due to genetic copying errors which may increase in number after repeated spermatogenesis cycles over a man's lifetime.Contents[hide]1 Disorders correlated with paternal age2 See also3 References4 External links//[edit] Disorders correlated with paternal ageAchondroplasia (dwarfism); craniofacial disorders such as Apert syndrome and Crouzon Syndrome; mental retardation of unknown etiologies; autism; and 25% of schizophrenia cases are correlated with advanced paternal age.Other disorders related to advanced paternal age are:Wilms' tumorThanatophoric dysplasiaRetin...
Paternal Legacy
2007-09-12 17:45:00 ‘Twas a good visit. Really. Seriously. Eight days scheduled non-stop fun with my parents just as the kids and I were getting ready for school might not have been a bright idea on my part, but it... Such a tease, I know. Want to read the rest? See photos? Watch video? Read more at the source: United States of Motherhood.
Is the mutated gene due to paternal contribution or the mutational contrubu
2007-09-12 03:23:00 The Wellcome Trust does not mention whether paternal or maternal age is involved.Mutations in the Insulin Gene Can Cause Neonatal Diabetes• Diabetes news • Sep 11, 2007Ten previously unknown mMutations in the insulin gene can cause permanent neonatal diabetes, an unusual form of type 1 diabetes that affects very young children and results in lifelong dependence on insulin injections, report researchers from the University of Chicago and Peninsula University (Exeter, UK) in Sept. 18, 2007, issue of the Proceedings of the National Academy of Sciences, published early online.Although abnormal insulin has been associated with milder cases of type 2 diabetes since the discovery of “insulin Chicago” in 1979, this is the first time that an insulin mutation has been connected to severe diabetes with onset early in life.type-1 diabetes. The researchers describe the10 mutations, found in 221 patients from 16 families., and show how several of the mutations alter the way the protein fo...
New Mutations and Paternal Age 1979 It is old news that paternal age cause
2007-09-08 20:52:00 : J Med Genet. 1979 Apr;16(2):147-8.LinksPaternal age effect in fibrodysplasia ossificans progressiva.Rogers JG, Chase GA.Analysis by the method of Smith (1972) of birth order and parental age data collected from 38 of 42 patients with fibrodysplasia ossificans progressive shows a significant paternal age effect. This finding among the sporadically occurring cases would support the proposition that this condition usually arises as a new dominant mutation.PMID: 287808 [PubMed - indexed for MEDLINE]
The Truth About the Genetic Connection Between PATERNAL AGE and Autism etc.
2007-09-05 19:56:00 Psychiatr Genet. 2005 Jun;15(2):117-25. LinksPaternal age and intelligence: implications for age-related genomic changes in male germ cells.Malaspina D, Reichenberg A, Weiser M, Fennig S, Davidson M, Harlap S, Wolitzky R, Rabinowitz J, Susser E, Knobler HY.New York State Psychiatric Institute and Columbia University, New York, NY 10032, USA. dm9@columbia.eduBACKGROUND: A robust association between advancing paternal age and schizophrenia risk is reported, and genetic changes in the germ cells of older men are presumed to underlie the effect. If that is so, then the pathway may include effects on cognition, as those with premorbid schizophrenia are reported to have lower intelligence. There are also substantial genetic influences on intelligence, so de novo genetic events in male germ cells, which accompany advancing paternal age, may plausibly influence offspring intelligence. OBJECTIVE: An association of paternal age with IQ in healthy adolescents may illuminate the mechanisms that...
Lisa Jo Rudy -- Does a Good Job, She Doesn't Know About All The Paternal Ag
2007-08-31 04:51:00 http://autism.about.com/od/caus-esofautism/f/parentage.htmDo older parents run a higher risk of having a child with autism?A. According to recent research, the answer is a qualified "yes." Several studies do seem to suggest that there is an association between parental age and autism. An association, though, is NOT the same thing as a causal connection. That means while older parents may be statistically more likely to have children with autism, no one knows why -- and the reasons may not relate to every couple.Why would an older parent be more likely to have a child with autism? One possible answer lies in research that shows children with autism are far more likely than typical children to have new (not inherited) genetic mutations. New genetic mutations are often the result of damage to eggs and sperm...........
MANY RESEARCHERS HAVE TRIED TO WARN THE PUBLIC ABOUT PATERNAL AGE CREATING
2007-08-30 17:44:00 By age 45 and up Red flags should go up about the dangers to many offspring because the odds of neurocognitive damage which become significant at paternal age 35 are far greater and increase with paternal age.The assertion that researchers do not know the cause of spontaneous mutations which are also called sporadic or germ line or de novo or non-familial mutations is erroneous. By the age of 45 offspring are 500 to 800% more likely to be autistic or schizophrenic or have other de novo genetic disorder too numerous to name. The autism/Asperger's/schizophrenia-/type 1 diabetes epidemics are not like lightening strikes at all. Why do the researchers like Michael Wigler, Jonathan Sebat etc. play dumb about spontaneous mutations and paternal age?Not fathering babies at Paternal ages over 30, 34, 35, before 40 has been advised by a great many researchers in the know! This knowledge has accumulated in the published scientific record since 1955 and may have been known since the 19th centu...
Please Read About the Strong Paternal Age Effect in Creating Spontaneous M
2007-08-28 08:02:00 It is unbelievable that Jonathan Sebat does not know that spontaneous mutations are known to increase with increasing paternal age past the age of 30. They are not mysterious, paternal age effect is well known. "So far, says researcher Dr. J. Sebat, there is no indication of why these mutations occur - or whether they are on the rise." This statement is blatantly misleading.Proc. Natl. Acad. Sci. USAVol. 94, pp. 8380-8386, August 1997ReviewThe high spontaneous mutation rate: Is it a health risk?*James F. CrowGenetics Laboratory, University of Wisconsin, Madison, WI 53706ABSTRACTFOOTNOTESACKNOWLED-GEMENTSREFERENCESABSTRACT The human mutation rate for base substitutions is much higher in males than in females and increases with paternal age. This effect is mainly, if not entirely, due to the large number of cell divisions in the male germ line. The mutation-rate increase is considerably greater than expected if the mutation rate were simply proportional to the number of cell division...
The Bronx Is Burning, Billy Martin, & the Misleading ?Paternal Abandonment
2007-08-27 19:02:00 I’ve often criticized what one might call the “paternal abandonment script”–the standard assumption that if a father doesn’t remain in his children’s lives after a divorce or separation, it’s because he “abandoned the family” and/or chose to remove himself from his children’s lives. One example is my blog entry Dick Allen & the Misleading ‘Paternal ...
Genetic Disorders Associated with Advanced Paternal Age - Tuberous Sclerosi
2007-08-25 20:01:00 It is not parental germ line mutations it is paternal germ line mutations that cause autism. The mother's fathers age or the fathers age.SYNDROMES WITH REPRODUCTIVE DYSFUNCTIONPaul J. Turek M.D.Associate Professor, Departments of Urology, Obstetrics, Gynecologyand Reproductive Sciences, University of California San FranciscoTable 1. Selected Genetic Disorders Associated with Advanced Paternal AgeAchondroplasias AniridiaApert syndrome Bilateral RetinoblastomaCrouzon syndrome Fibrodysplaisa OssificansHemophilia A Lesch Nyhan syndromeMarfan syndrome NeurofibromatosisOculodentodigi-tal syndrome Polycystic kidney diseasePolyposis coli ProgeriaTreacher-Collins syndrome Tuberous sclerosisWardenburg syndromeFormal risk estimates for the contribution that advanced paternal age makes to autosomaldominant mutations have been calculated. Friedman estimated that in men 45 (22). The risk for a father over 40 years old tohave a child with an autosomal dominant mutation equals the risk of Down sy...
NEW PAPER Older Paternal Age and Schizophrenia, CNVs, Point Mutations,Dysre
2007-08-24 02:02:00 Schizophr Bull. 2007 Aug 21; [Epub ahead of print]Aberrant Epigenetic Regulation Could Explain the Relationship of Paternal Age to Schizophrenia.Perrin MC, Brown AS, Malaspina D.2Department of Psychiatry, School of Medicine, New York University, New York, NY.The causal mechanism underlying the well-established relation between advancing paternal age and schizophrenia is hypothesized to involve mutational errors during spermatogenesis that occur with increasing frequency as males age. Point mutations are well known to increase with advancing paternal age while other errors such as altered copy number in repeat DNA and chromosome breakage have in some cases also been associated with advancing paternal age. Dysregulation of epigenetic processes may also be an important mechanism underlying the association between paternal age and schizophrenia. Evidence suggests that advancing age as well as environmental exposures alter epigenetic regulation. Errors in epigenetic processes, such as pa...
Advanced paternal age was associated with increased risk of ASD. Possible b
2007-08-19 07:37:00 age or alterations in genetic imprinting.Advancing maternal age showed no association with ASD after adjusting for paternal age.: Arch Gen Psychiatry. 2006 Sep;63(9):1026-32. LinksAdvancing paternal age and autism.Reichenberg A, Gross R, Weiser M, Bresnahan M, Silverman J, Harlap S, Rabinowitz J, Shulman C, Malaspina D, Lubin G, Knobler HY, Davidson M, Susser E.Department of Psychiatry and Seaver Center for Autism Research, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA. avi.reichenberg@mssm.eduCONTEXT-: Maternal and paternal ages are associated with neurodevelopmental disorders. OBJECTIVE: To examine the relationship between advancing paternal age at birth of offspring and their risk of autism spectrum disorder (ASD). DESIGN: Historical population-based cohort study. SETTING: Identification of ASD cases from the Israeli draft board medical registry. PARTICIPANTS: We conducted a study of Jewish persons born in Israel during 6 consecutive years. Vir...
Importantly, disorders linked to advancing paternal age begin to increase r
2007-08-18 23:16:00 There is enough research to urge men and women who want children to have them in their twenties and very early 30s. It doesn't matter if there are 100 papers finding that paternal age is the major cause of spontaneous mutations because it is not an idea that is popular.The latest finding, published last month: Older fathers are more likely to have children with autism. Researchers tracked 387,000 people born in Israel and concluded the odds of fathering an autistic child are about 6 in 1,000 for men under 20. When a man reaches 50, those odds shoot up to about 52 in 1,000."The optimal time for a man to father a healthy child is the same as for a woman — 25 or so," says Dolores Malaspina, a psychiatry professor at New York University and coauthor of the study.Some of the statistics are quite alarming, however. Of the nearly 6 million fertility problems in the US each year, roughly 40% of them are attributed to the man. Of all the babies born with Down Syndrome to women over the ag...
Deletions are Manly Caused By Increasing Paternal Age
2007-08-15 07:21:00 Published by the University of Chicago PressTitleSimultaneous Discovery and Testing of Deletions for Disease Association in SNP Genotyping StudiesAuthor(s)Jared R. Kohler and David J. CutlerIdentifiersThe American Journal of Human Genetics, volume 81 (2007), page 000 DOI: 10.1086/520823AvailabilityThis- site: PS HTML PDF (1.4M)Copyright© 2007, The American Society of Human Genetics.AbstractCopy-number variation (CNV), and deletions in particular, can play a crucial, causative role in rare disorders. The extent to which CNV contributes to common, complex disease etiology, however, is largely unknown. Current techniques to detect CNV are relatively expensive and time consuming, making it difficult to conduct the necessary large-scale genetic studies. SNP genotyping technologies, on the other hand, are relatively cheap, thereby facilitating large study designs. We have developed a computational tool capable of harnessing the information in SNP genotype data to detect deletions....
Irrefutable evidence of a paternal age effect on genetic disorders in offsp
2007-08-14 03:06:00 There is as much evidence that sperm mutations increase with paternal age as there are repercussions if you drink and drive at the same time. There is irrefutable evidence that genetic disorders increase in offspring of older fathers with increasing paternal age. Look up paternal age and genetic disorders on this blog or google it.Paternal age effectFrom Wikipedia, the free encyclopedia(Redirected from Paternal age)Jump to: navigation, searchThe paternal age effect describes the influence that a father's age has on the chances of conferring a genetic defect to his offspring. Generally, older men have a greater probability of fathering children with a genetic defect than younger men do.[citation needed] This is seen as likely due to genetic copying errors which may increase in number after repeated spermatogenesis cycles over a man's lifetime.Contents[hide]1 Disorders correlated with paternal age2 See also3 References4 External links//Disorders correlated with paternal ageAchondrop...
After Months of Harping on Paternal Age I shift to include the role of Vacc
2007-08-11 22:04:00 "In 1948 two Harvard Medical School scientists, Randolph Byers and Frederick Moll carried out tests on the DPT at Children’s Hospital in Boston and concluded that severe neurological problems followed administration of the vaccine. The results were published in Pediatrics, a respectable medical journal. The results were completely ignored by the medical and pharmaceutical community. In 1976, Charles Manclark, an FDA scientist, remarked, “The DPT had one of the worst failure rates of any product submitted to the Division of Biologics for testing.”
Who is Hiding the Truth About Paternal Age and Genetic Disorders?
2007-08-08 19:45:00 What causes Alzheimer's, Diabetes, Autism, Schizophrenia, Prostate Cancer, Breast Cancer, Multiple Sclerosis, ALL, Hemophilia, Duchennes, Retinoblastoma, Progeria, Huntington's chorea,etc. etc. Why do they all rise in non-familial cases with paternal age and why does the public not know? Rising paternal age past 30 is related to autism etc. the way sun exposure and Vitamin D is related. There is no question that sperm stem cells collect mutations/copy number variations with a man's age and toxic exposures. There are papers from the 1950s on and many since 2000 on all aspects of this topic and no reputable research has not found that genetic disease is related to increasing paternal age at conception. Take some time and look it up, don't take my word for it.Winning Cartoon
Older paternal age and Older maternal grandfather's age plus family histori
2007-08-07 05:57:00 etc. etc. Don't delay to research this topic for yourself and look at the issue of vaccinations for yourself.
Patterson Fails To Mention Increasing Paternal Age At The Time of Conceptio
2007-07-17 03:24:00 Dr. Patterson neglects a robust risk factor responsible for up one third and maybe by now more than one third of all cases. Dolores Malaspina M.D. Chair of N.Y.U. Department of Psychiatry:"What is the most irrefutable finding that you and your colleagues have made?""The most irrefutable finding is our demonstration that a father’s age is a major risk factor for schizophrenia. We were the first group to show that schizophrenia is linearly related to paternal age and that the risk is tripled for the offspring of the oldest groups of fathers.7 This finding has been born out in every single cohort study that has looked at paternal age and the risk for schizophrenia. The only other finding that has been as consistently replicated in schizophrenia research is that there is an increased risk associated with a family history of schizophrenia. Since only 10% to 15% of schizophrenia cases have a family history, family history does not explain much of the population risk for schizophrenia. H...
Do Copy Number Variations Increase With Older Paternal Age, Is That Why Non
2007-07-11 20:13:00 Canadian, British And American Scientists Launch Major New Genome Partnership To Catalogue All Common Copy Number VariationsMain Category: Genetics NewsAn international team will use state-of-the-art, high-density microarrays and new computer algorithms to improve the detection of variants in the human genome which are implicated in various diseases. The new systems are the foundation of Phase 2 of the Genome Structural Variation Consortium, which was set up in 2004 and seeks to identify structurally variable regions in the human genome. In 2006, the Genome Structural Variation Consortium, along with other international collaborators, generated a first-generation map of copy number variants (CNVs) covering the human genome. The CNVs that they identified, which in many cases lead to deletion or duplication of genes along chromosomes, tended to encompass large stretches of DNA ranging from thousands to millions of chemical bases of DNA. These changes are part of the normal variability...
"Scientists have linked paternal age to genetic d...
2007-07-09 22:07:00 "Scientists have linked paternal age to genetic diseases since the 1950s......"(Great Neck, NY - March 23, 2006) — Scientists have linked paternal age to genetic diseases since the 1950s, and some have suggested an association between the age of the father and the risk for schizophrenia. In 2001, Dolores Malaspina, M.D., M.P.H., and her colleagues reported their research identifying a relationship between paternal age and the occurrence of schizophrenia. On behalf of Medscape* Jessica Gould interviewed Dr. Malaspina, Professor of Clinical Psychiatry at Columbia University and Research Psychiatrist at New York State Psychiatric Institute in New York City. Dr. Malaspina elaborates on her research and speaks about new directions in genetic research on schizophrenia. (NARSAD NOTE: Dr. Malaspina was a NARSAD 1993 and 1995 Young Investigator and a 2001 Independent Investigator.)
Pulmonary Arterial Hypertension and Mutation in BMPR2 gene Is Paternal Age
2007-07-04 22:52:00 "New Point Mutations in Humans Are Introduced Through The Male Line" This Has Been Known Since the 1950s", "What is Intriguing is why society chooses to ignore this" Dolores MalaspinaPulmonary arterial hypertension or PAH is not a common disease that people are aware of readily although it affects perhaps close to 800,000 people in the USA—at least those that are diagnosed. Women are more at risk than men for this disease. A mutation in the BMPR2 gene is said to cause PAH.What happens is that the pulmonary artery, which carries blood from the heart to the lungs, is affected by hypertension. This latter happens because the small arteries in the lungs become narrower in diameter so naturally there is an increase in resistance of the blood flow through the lungs. To combat this situation pressure goes up in the artery and in the right ventricle, which helps to pump blood into the artery.A person is affected because the increased resistance cannot be offset by the increased pressure, ...
High Paternal Age is Causing More Type 1 Diabetes in non-Hispanic White Chi
2007-06-27 21:05:00 : Diabetes Care. 2007 Mar;30(3):503-9. LinksIncreasing incidence of type 1 diabetes in 0- to 17-year-old Colorado youth.Vehik K, Hamman RF, Lezotte D, Norris JM, Klingensmith G, Bloch C, Rewers M, Dabelea D.University of Colorado School of Medicine, Denver, Colorado, USA.OBJECTIVE: We sought to assess the long-term trends in the incidence of type 1 diabetes among non-Hispanic white and Hispanic youth aged 0-17 years from Colorado using data from the Colorado IDDM Study Registry (1978-1988) and SEARCH for Diabetes in Youth (2002-2004). RESEARCH DESIGN AND METHODS: Cases of diabetes were ascertained through physician reporting and hospital databases. Type 1 diabetes was defined as use of insulin within 2 weeks from diagnosis. Completeness of ascertainment was estimated as 97%. Annual average incidence rates (per 100,000/year) and 95% CIs for the time periods were computed. Trends in incidence were assessed by Poisson regression. RESULTS: The incidence of type 1 diabetes was 14.8 (95% ...
"I am aware of the paternal age effect in many disorders and in the case of
2007-06-26 05:53:00 Professor Angus ClarkePrincipal Investigator and Professor in Clinical GeneticsAngus Clarke was born in 1954. He studied Medical and Natural Sciences in Cambridge, taking his Part II in Genetics, and then qualified in Medicine from Oxford University in 1979. After registration, he worked in general medicine and then paediatrics. As a research registrar in the Department of Medical Genetics in Cardiff, he studied the clinical and molecular genetic aspects of ectodermal dysplasia. Subsequently, he worked in clinical genetics and paediatric neurology in Newcastle upon Tyne, developing an interest in Rett syndrome and neuromuscular disorders. He returned to Cardiff in 1989 as Senior Lecturer in Clinical Genetics. He is now Professor in Clinical Genetics. As well as teaching he also works as a clinician. With his colleague, Peter Harper, he wrote the book, Genetics, Society and Clinical Practice. He directs the Cardiff MSc course in Genetic Counselling.Research interests:social and ethic...
Sean Connery Declines Paternal Role in ?Indiana Jones 4?
2007-06-08 03:43:00 ?Indiana Jones 4? ? a film I?ve been tracking with much interest ? has officially lost its sage father figure. On Thursday, Sean Connery declined the role of Harrison Ford?s dad. Connery reasoned the decision with the following:I thought long and hard about it, and if anything could have pulled me out of retirement, it would have been an Indiana Jones film.I love working with Steven and George. It goes without saying that it is an honor to have Harrison as my son. In the end, retirement is just too damned much fun.I do, however, have one bit of advice for Junior: Demand that the critters be digital, the cliffs be low and for goodness sake keep that whip by your side at all times in case you need to escape from the stunt coordinator.I can only say ?break a leg, everyone?. I?ll see you on May 22, 2008 at the theater.We knew previously the film had cast Harrison Ford, Shia LeBeouf and Cate Blanchett. Now we also know it has signed on John Hurt and Ray Winstone. I love this franchise an...
Increasing Paternal Age Associated With Decreased Learning Capacity in 1989
2007-06-06 22:45:00 Hum Reprod. 1989 Oct;4(7):794-7. Links Paternal age and mental functions of progeny in man.Auroux MR, Mayaux MJ, Guihard-Moscato ML, Fromantin M, Barthe J, Schwartz D. Biologie de la Reproduction et du Developpement, CHU Bicetre, Le Kremlin-Bicetre, France.Hum Reprod. 1989 Oct;4(7):794-7. LinksPaternal age and mental functions of progeny in man.Auroux MR, Mayaux MJ, Guihard-Moscato ML, Fromantin M, Barthe J, Schwartz D.Biologie de la Reproduction et du Développement, CHU Bicêtre, Le Kremlin-Bicêtre, France.The effects of maternal age on the quality of offspring are well known. Those due to the father's age are less obvious, apart from the role of increasing paternal age in the onset of many dominant autosomal disorders. But an experimental model has demonstrated that, in rats, increasing paternal age, without any other anomalies, might produce a decreased learning capacity in progeny. The object of the epidemiological investigation presented here was to verify whether this effe...
This May Have Nothing To Do With Paternal Age and Autism But It Does Have t
2007-06-05 06:05:00 medicine and the lack total of it in a great deal of psychiatry and academic research as well as pharmaRoot Strikers"There are a thousand hacking at the branches of evil to one who is striking at the root"Henry David ThoreauThis post is about our patients and their questions.It is about the honesty of our profession.
Wikipedia on Paternal Age
2007-06-03 03:47:00 Paternal ageFrom Wikipedia, the free encyclopediaJump to: navigation, searchThis article (or section) may need to be wikified to meet Wikipedia's quality standards.Please help improve this article, especially its section layout, and relevant internal links. (help)This article has been tagged since December 2006. Contents [hide]1 Paternal Age Effect 2 Causes 3 Disorders Correlated With Paternal Age 4 References 5 External links [edit] Paternal Age EffectScientists know that a woman’s age at the time she conceives can affect her offspring’s genetic make-up. Women age 35 and older are at greater risk of delivering a child with a genetic disorder, such as Down Syndrome, due to an incorrect number of chromosomes. Less well known is that a man’s advanced age affects his offspring even more so than a woman's, on average. In what is called the paternal age effect, men 30 years and older have a greater probability than younger men of fathering a child with some kind of genetic defec...
OLDER DADS PAST 33 THE RISKS RISE WITH INCREASING PATERNAL AGE
2007-05-26 22:42:00 The link between schizophrenia and older paternity had been made before, but this was the first large study to look at a range of factors that could confound the results, said Professor John McGrath, a psychiatric epidemiologist at the Queensland Centre for Mental Health Research."If all babies had fathers less than 30, the paper suggests, the incidence of schizophrenia would reduce by 15 per cent," he said.In 2002 the average age of fathers was 32, compared with an average age of 29 in 1982, according to data from the Australian Bureau of Statistics.The executive director of the mental health lobby group SANE Australia, Barbara Hocking, said the Swedish research, published in the British medical journal BMJ, was "major, major stuff". She likened the research to the link between mothers over 35 and an increased risk of Down syndrome in their children. "It helps people understand what risk factors may be, so you can take action to reduce them."Obstetrics & Gynecology 1981;57:745-749 ...
POSSIBILITY THAT PATERNAL SMOKING CAUSES MUTATIONS IN SPERM THAT LEAD TO CA
2007-05-25 21:15:00 1: Mutat Res. 1996 Apr 13;351(2):199-203. Links Smoking and low antioxidant levels increase oxidative damage to sperm DNA.Fraga CG, Motchnik PA, Wyrobek AJ, Rempel DM, Ames BN. Fisicoquimica, Facultad de Farmacia y Bioquimica, Universidad de BuenosAires, Argentina.Our previous studies have shown that men with low ascorbate intake have markedly increased oxo8dG in the DNA of their sperm. Because cigarette smoke is high in oxidants and depletes plasma and tissue antioxidants, oxidative DNA damage in sperm and tocopherol and ascorbate levels in seminal plasma were determined in smokers and non-smokers. The level in sperm DNA of oxo8dG, an oxidative lesion of guanine, was 50% higher in smokers compared to nonsmokers (p = 0.005). The concentration of alpha-tocopherol in seminal plasma was decreased in smokers by 32% (p = 0.03). Smoking and low antioxidant levels increase oxidative damage to sperm DNA. We discuss the possibility that paternal smoking causes mutations in sperm that lead t...
Slight but significant increases in disomy frequency with advancing paterna
2007-05-25 20:20:00 Aneuploidy in human sperm: a review of the frequency and distribution of aneuploidy, effects of donor age and lifestyle factorsQ. Shi, R.H. MartinDepartment of Medical Genetics, Faculty of Medicine, University of Calgary, and Genetics Department, Alberta Children's Hospital, Calgary, Alberta (Canada) Abstract.Application of fluorescence in situ hybridization (FISH) analysis has opened the way for comprehensive studies on numerical chromosome abnormalities in human sperm. During the last decade, more than five million sperm from approximately 500 normal men were analyzed by a number of laboratories from around the world by this approach. Except for chromosome 19 which has been analyzed in only one study, all other chromosomes have been examined by two or more studies with considerable differences in disomy frequency for an individual chromosome among studies. The mean disomy frequency is 0.15% for each of the autosomes and 0.26% for the sex chromosomes. Most chromosomes analyzed ha...
Advanced Paternal Age was noted for the fathers of patients with Crouzon or
2007-05-25 03:58:00 OUR RESULTS SUGGEST THAT OLDER FATHERS HAVE ACCUMULATED OR ARE MORE SUSCEPTIBLE TO A VARIETY OF GERM LINE MUTATIONSPublished by the University of Chicago Press----------------------------------------------------------------------------------Title Paternal Origin of FGFR2 Mutations in Sporadic Cases of Crouzon Syndrome and Pfeiffer Syndrome Author(s) Rivka L. Glaser, Wen Jiang, Simeon A. Boyadjiev, Alissa K. Tran, Andrea A. Zachary, Lionel Van Maldergem, David Johnson, Sinead Walsh, Michael Oldridge, Steven A. Wall, Andrew O. M. Wilkie, and Ethylin Wang Jabs Identifiers The American Journal of Human Genetics, volume 66 (2000), pages 768–777 DOI: 10.1086/302831PubMed ID: 10712195 Availability This site: PS | HTML | PDF (303.3k) Copyright © 2000, The American Society of Human Genetics. Abstract Crouzon syndrome and Pfeiffer syndrome are both autosomal dominant craniosynostotic disorders that can be caused by mutations in the fibroblast growth factor receptor 2 (FGFR2) gen...
Three Sporadic Cases of Achondroplasia average paternal age 35.86 all mutat
2007-05-25 03:45:00 this study was 35.86 years, suggesting an advancedpaternal age effect. Mutations in Fibroblast Growth-Factor Receptor 3 in Sporadic Cases of Achondroplasia Occur Exclusively on the Paternally Derived Chromosome Author(s) Douglas J. Wilkin, Jinny K. Szabo, Rhoda Cameron, Shirley Henderson, Gary A. Bellus, Michelle L. Mack, Ilkka Kaitila, John Loughlin, Arnold Munnich, Bryan Sykes, Jacky Bonaventure, and Clair A. Francomano Identifiers The American Journal of Human Genetics, volume 63 (1998), pages 711–716 DOI: 10.1086/302000PubMed ID: 9718331 Availability This site: PS | HTML | PDF (535.4k) Copyright © 1998, The American Society of Human Genetics. Abstract More than 97% of achondroplasia cases are caused by one of two mutations (G1138A and G1138C) in the fibroblast growth factor receptor 3 (FGFR3) gene, which results in a specific amino acid substitution, G380R. Sporadic cases of achondroplasia have been associated with advanced paternal age, suggesting that these mut...
MORE MONEY WHEN ANNOUNCING TO THE PUBLIC TO LOWER PATERNAL AGE WOULD DO THE
2007-05-25 01:16:00 Broad Foundation Gift to Establish Asperger Research Center at UC Santa BarbaraSANTA BARBARA, Calif. – The Gevirtz Graduate School of Education’s Koegel Autism Center at the University of California, Santa Barbara announced today it has received a $940,000 gift from The Eli and Edythe Broad Foundation to establish the Eli and Edythe L. Broad Center for Asperger Research.The new center will be the first research and training facility in the United States devoted to developing treatments and ultimately finding a cure for individuals with Asperger’s Syndrome, a prevalent form of high functioning autism characterized by difficulties with social communication.Led by international autism authorities Drs. Robert and Lynn Koegel, the Broad Center will develop and refine the Koegels’ research-based model for intervention and support for children and adults with Asperger’s Syndrome.“Edye and I are pleased to create a center that will support the Koegels’ innovative research into...
Does increasing paternal age causes CNVs that are deleterious to develop in
2007-05-24 23:03:00 Standing on a spiral staircase inspired by the helical structure of DNA, Charles Lee (right) and John Iafrate discuss the surprising gaps they found in the human genome. The gaps may explain some of the differences in human nature, as well as to identify people who are prone to certain diseases, including cancer. (Staff photo Stephanie Mitchell/Harvard News Office) Surprising variations discovered in human genomes Unexpected DNA losses and gains found By William J. Cromie Harvard News Office Contrary to expectations, a startling number of large variations have been found in the human genome. The genetic blueprints for humans were thought to be 99.9 percent similar, but researchers at Harvard Medical School and the University of Toronto in Canada have accidentally discovered large chunks of missing or added DNA in normal, healthy people."We were extraordinarily surprised to see that some people have so much more or less DNA," says Charles Lee, a geneticist and assistant professor at ...
PATERNAL AGE EFFECT IN SOME CEREBRAL PALSY- ATHETOID/DYSTONIC - HEMIPLEGIC
2007-05-24 20:26:00 1: J Med Genet. 1993 Jan;30(1):44-6. Links Parental age, genetic mutation, and cerebral palsy.Fletcher NA, Foley J. Department of Neurological Sciences, St Bartholomew's Hospital, London.Parental age and birth order were studied in 251 patients with cerebral palsy. No parental age or birth order effects were observed in spastic quadriplegia or diplegia, but a paternal age effect was detected in those with athetoid/dystonic cerebral palsy and congenital hemiplegia. These observations indicate that some cases of athetoid/dystonic or hemiplegic cerebral palsy might arise by fresh dominant genetic mutation.Dev Med Child Neurol. 1996 Oct;38(10):873-80. Links Comment in: Dev Med Child Neurol. 1996 Oct;38(10):871-2. Dyskinetic cerebral palsy: a clinical and genetic study.Fletcher NA, Marsden CD. Walton Centre for Neurology and Neurosurgery, Liverpool, UK.The clinical features and family histories of 20 adults with dyskinetic cerebral palsy from 20 families were studied. The majority of th...
High Paternal Age May be Associated with Sporadic Bilateral Retinoblastoma
2007-05-23 05:32:00 : Ophthalmic Epidemiol. 2000 Dec;7(4):285-91. Links Parental age in Indian patients with sporadic hereditary retinoblastoma.Sivakumaran TA, Ghose S, Kumar H, A S, Kucheria K. Division of Genetics, Department of Anatomy, Dr. Rajendra Prasad Centre for Ophthalmic Science, All India Institute of Medical Sciences, New Delhi, India.There is a consistent correlation between sporadic hereditary retinoblastoma and parental age. It has been proven beyond doubt that the birth rank is correlated with parental age. In the present study, a test for the effect of birth rank was performed in order to assess the risk of developing retinoblastoma with increased parental age. The study of the effect of birth rank showed a significant association between sporadic retinoblastoma (bilateral and unilateral) and late para, indicating that fresh germline mutations must have taken place in some of the sporadic cases. An investigation of the effect of birth rank on familial cases, obtained from published pap...
NRXN-1 not likely to have anything to do with paternal age
2007-05-23 04:49:00 The neurexin deletions in the two sisters are not point mutations. Point mutations affect only a single nucleotide or just a few nucleotides. The deletion in these neurexin cases involved 450,000 nucleotides.It is very unlikely that two new mutations of the same gene in two different children (except identical twins) would occur under any circumstances. These cases probably represent gonadal mosaicism in one of the parents (assuming both were tested and neither carries the same deletion).Moreover, I know of no evidence that deletions of the type that apparently occurred in these girls have anything to do with the age of either parent.
Sir John Sulston What does he know or think about the paternal age effect
2007-05-22 21:32:00 PMID: 16710554 [PubMed - indexed for MEDLINE] SIR JOHN SULSTON: PROFILEWednesday 24 November 2004 2.10am-2.40am (Tuesday night) John Sulston has a knighthood, a Nobel Prize and the credit for uncovering our genetic instructions for life. His mapping of the human genome has put him at the forefront of scientific endeavour. But Sulston remains happiest away from the awards platform and behind his microscope. A Guardian-reading, muesli-chomping, self-confessed "nerd turned hippie", he is very much what fellow Nobel Laureate Paul Nurse calls "a scientist's scientist".Worm work The son of a vicar and a teacher, Sulston was, at an early age, imbued with a strong moral code and curiosity for how things work. When he arrived in the research labs of Cambridge, he discovered his vocation in the unlikely form of the nematode worm. Tracking the worm's cellular development took Sulston eight hours a day. Eighteen months later, he had made some radical discoveries about cell lineage i... |
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